Normocholesterolemic tendon xanthomatosis with overproduction of apolipoprotein B

Gloria L Vega, D. Roger Illingworth, Scott M Grundy, Frank T. Lindgren, William E. Connor

Research output: Contribution to journalArticle

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Abstract

This report describes a 46-yr-old man with normocholesterolemic tendon xanthomatosis. He had severe bilateral xanthomas of Achilles tendons and small lesions on patellar tendons; biopsy of the latter revealed a fibroxanthoma of high cholesterol content. He did not have clinical evidence of atherosclerotic disease. The patient's total cholesterol (TC) and triglycerides (TG) were 245 and 258 mg/dl, respectively. LDL-TC was 168 mg/dl and HDL-TC was 32 mg/dl. VLDL consisted mainly of small particles (Sf o 20-100) which were unusually rich in apolipoproteins B and E (and low in apo Cs). Plasma LDL-apo B was not increased (85-120 mg/dl), but VLDL-apo B was distinctly elevated (58 mg/dl). The synthesis rate of apoLDL (29.9 mg/kg/d) was increased markedly compared to a matched control (13.9 mg/kg/d) and to a patient with familial hypercholestrolemia (15.9 mg/kg/d). The concentration of apoLDL in our patient was not increased; this was because of an associated high FCR (0.484 day-1). His HDL was relatively low in TC but high in TG, which caused an increase in HDL2b. The patient's xanthomata may have been the result of an overproduction of apo B possibly combined with a defect in HDL metabolism.

Original languageEnglish (US)
Pages (from-to)118-125
Number of pages8
JournalMetabolism
Volume32
Issue number2
DOIs
StatePublished - 1983

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Xanthomatosis
Apolipoproteins B
Tendons
Cholesterol
Triglycerides
Patellar Ligament
Achilles Tendon
Apolipoproteins E
LDL Cholesterol
HDL Cholesterol
Biopsy

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Cite this

Normocholesterolemic tendon xanthomatosis with overproduction of apolipoprotein B. / Vega, Gloria L; Illingworth, D. Roger; Grundy, Scott M; Lindgren, Frank T.; Connor, William E.

In: Metabolism, Vol. 32, No. 2, 1983, p. 118-125.

Research output: Contribution to journalArticle

Vega, Gloria L ; Illingworth, D. Roger ; Grundy, Scott M ; Lindgren, Frank T. ; Connor, William E. / Normocholesterolemic tendon xanthomatosis with overproduction of apolipoprotein B. In: Metabolism. 1983 ; Vol. 32, No. 2. pp. 118-125.
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