Not without cause

Vibrio parahaemolyticus induces acute autophagy and cell death

Dara L. Burdette, Melanie L. Yarbrough, Kim Orth

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Vibrio parahaemolyticus (V. parahaemolyticus) is a gram-negative halophillic bacterium that causes worldwide seafood-borne gastroenteritis. The prevalence of V. parahaemolyticus in the environment and incidence of infection have been linked to rising water temperatures caused by global warming. Among its virulence factors, V. parahaemolyticus harbors two type III secretion systems (T3SS). Recently, we have shown that T3SS1 induces rapid cellular death that initiates with acute autophagy, as measured by LC3 lipidation and accumulation of early autophagosomal vesicles. While not the first characterized pathogen to usurp autophagy, this is the first example of an extracellular pathogen that exploits this pathway for its own benefit. Here we discuss possible roles for the induction of autophagy during infection and discuss how V. parahaemolyticus-induced autophagy provides insight into key regulatory steps that govern the decision between apoptosis and autophagy.

Original languageEnglish (US)
Pages (from-to)100-102
Number of pages3
JournalAutophagy
Volume5
Issue number1
StatePublished - Jan 1 2009

Fingerprint

Vibrio parahaemolyticus
Autophagy
Cell Death
Global Warming
Seafood
Gastroenteritis
Virulence Factors
Infection
Gram-Negative Bacteria
Apoptosis
Temperature
Water
Incidence

Keywords

  • Apoptosis
  • Autophagy
  • Cell death
  • Infection
  • Proinflammatory
  • Type III secretion
  • Vibrio parahaemolyticus

ASJC Scopus subject areas

  • Cell Biology
  • Molecular Biology

Cite this

Not without cause : Vibrio parahaemolyticus induces acute autophagy and cell death. / Burdette, Dara L.; Yarbrough, Melanie L.; Orth, Kim.

In: Autophagy, Vol. 5, No. 1, 01.01.2009, p. 100-102.

Research output: Contribution to journalArticle

Burdette, DL, Yarbrough, ML & Orth, K 2009, 'Not without cause: Vibrio parahaemolyticus induces acute autophagy and cell death', Autophagy, vol. 5, no. 1, pp. 100-102.
Burdette, Dara L. ; Yarbrough, Melanie L. ; Orth, Kim. / Not without cause : Vibrio parahaemolyticus induces acute autophagy and cell death. In: Autophagy. 2009 ; Vol. 5, No. 1. pp. 100-102.
@article{8c5e7097c63340439e1e31451a8159cf,
title = "Not without cause: Vibrio parahaemolyticus induces acute autophagy and cell death",
abstract = "Vibrio parahaemolyticus (V. parahaemolyticus) is a gram-negative halophillic bacterium that causes worldwide seafood-borne gastroenteritis. The prevalence of V. parahaemolyticus in the environment and incidence of infection have been linked to rising water temperatures caused by global warming. Among its virulence factors, V. parahaemolyticus harbors two type III secretion systems (T3SS). Recently, we have shown that T3SS1 induces rapid cellular death that initiates with acute autophagy, as measured by LC3 lipidation and accumulation of early autophagosomal vesicles. While not the first characterized pathogen to usurp autophagy, this is the first example of an extracellular pathogen that exploits this pathway for its own benefit. Here we discuss possible roles for the induction of autophagy during infection and discuss how V. parahaemolyticus-induced autophagy provides insight into key regulatory steps that govern the decision between apoptosis and autophagy.",
keywords = "Apoptosis, Autophagy, Cell death, Infection, Proinflammatory, Type III secretion, Vibrio parahaemolyticus",
author = "Burdette, {Dara L.} and Yarbrough, {Melanie L.} and Kim Orth",
year = "2009",
month = "1",
day = "1",
language = "English (US)",
volume = "5",
pages = "100--102",
journal = "Autophagy",
issn = "1554-8627",
publisher = "Landes Bioscience",
number = "1",

}

TY - JOUR

T1 - Not without cause

T2 - Vibrio parahaemolyticus induces acute autophagy and cell death

AU - Burdette, Dara L.

AU - Yarbrough, Melanie L.

AU - Orth, Kim

PY - 2009/1/1

Y1 - 2009/1/1

N2 - Vibrio parahaemolyticus (V. parahaemolyticus) is a gram-negative halophillic bacterium that causes worldwide seafood-borne gastroenteritis. The prevalence of V. parahaemolyticus in the environment and incidence of infection have been linked to rising water temperatures caused by global warming. Among its virulence factors, V. parahaemolyticus harbors two type III secretion systems (T3SS). Recently, we have shown that T3SS1 induces rapid cellular death that initiates with acute autophagy, as measured by LC3 lipidation and accumulation of early autophagosomal vesicles. While not the first characterized pathogen to usurp autophagy, this is the first example of an extracellular pathogen that exploits this pathway for its own benefit. Here we discuss possible roles for the induction of autophagy during infection and discuss how V. parahaemolyticus-induced autophagy provides insight into key regulatory steps that govern the decision between apoptosis and autophagy.

AB - Vibrio parahaemolyticus (V. parahaemolyticus) is a gram-negative halophillic bacterium that causes worldwide seafood-borne gastroenteritis. The prevalence of V. parahaemolyticus in the environment and incidence of infection have been linked to rising water temperatures caused by global warming. Among its virulence factors, V. parahaemolyticus harbors two type III secretion systems (T3SS). Recently, we have shown that T3SS1 induces rapid cellular death that initiates with acute autophagy, as measured by LC3 lipidation and accumulation of early autophagosomal vesicles. While not the first characterized pathogen to usurp autophagy, this is the first example of an extracellular pathogen that exploits this pathway for its own benefit. Here we discuss possible roles for the induction of autophagy during infection and discuss how V. parahaemolyticus-induced autophagy provides insight into key regulatory steps that govern the decision between apoptosis and autophagy.

KW - Apoptosis

KW - Autophagy

KW - Cell death

KW - Infection

KW - Proinflammatory

KW - Type III secretion

KW - Vibrio parahaemolyticus

UR - http://www.scopus.com/inward/record.url?scp=58149457054&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=58149457054&partnerID=8YFLogxK

M3 - Article

VL - 5

SP - 100

EP - 102

JO - Autophagy

JF - Autophagy

SN - 1554-8627

IS - 1

ER -