TY - JOUR
T1 - Not(ch) just development
T2 - Notch signalling in the adult brain
AU - Ables, Jessica L.
AU - Breunig, Joshua J.
AU - Eisch, Amelia J.
AU - Rakic, Pasko
N1 - Funding Information:
J.L.A. would like to thank the Medical Science Training Program (MSTP) at both the University of Texas Southwestern Medical Centre, at Dallas, Texas, USA, and Mount Sinai School of Medicine, New York, New York, USA, as well as the US National Institute of Mental Health (NIMH) and National Institute on Drug Abuse (NIDA) for their support. J.J.B. was supported by the Connecticut Stem Cell Research Grant Program during the preparation of this manuscript and is currently supported by the Cedars-Sinai Regenerative Medicine Institute, Los Angeles, California, USA. A.J.E. is supported by grants from the US National Institutes of Health (NIH), including grants from NIDA (DA016765, DA016765-07S, DA023555) and the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) (DK079328), the National Alliance for Research on Schizophrenia and Depression, the National Aeronautics and Space Administration, and the Norwegian Department of Public Health. P.R. is supported by grants from the US National Institute of Neurological Disorders and Stroke (NINDS), NIDA and the Kavli Institute of Neuroscience at Yale University School of Medicine, New Haven, Connecticut, USA.
PY - 2011/5
Y1 - 2011/5
N2 - The Notch pathway is often regarded as a developmental pathway, but components of Notch signalling are expressed and active in the adult brain. With the advent of more sophisticated genetic manipulations, evidence has emerged that suggests both conserved and novel roles for Notch signalling in the adult brain. Not surprisingly, Notch is a key regulator of adult neural stem cells, but it is increasingly clear that Notch signalling also has roles in the regulation of migration, morphology, synaptic plasticity and survival of immature and mature neurons. Understanding the many functions of Notch signalling in the adult brain, and its dysfunction in neurodegenerative disease and malignancy, is crucial to the development of new therapeutics that are centred around this pathway.
AB - The Notch pathway is often regarded as a developmental pathway, but components of Notch signalling are expressed and active in the adult brain. With the advent of more sophisticated genetic manipulations, evidence has emerged that suggests both conserved and novel roles for Notch signalling in the adult brain. Not surprisingly, Notch is a key regulator of adult neural stem cells, but it is increasingly clear that Notch signalling also has roles in the regulation of migration, morphology, synaptic plasticity and survival of immature and mature neurons. Understanding the many functions of Notch signalling in the adult brain, and its dysfunction in neurodegenerative disease and malignancy, is crucial to the development of new therapeutics that are centred around this pathway.
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U2 - 10.1038/nrn3024
DO - 10.1038/nrn3024
M3 - Review article
C2 - 21505516
AN - SCOPUS:79955040212
SN - 1471-003X
VL - 12
SP - 269
EP - 283
JO - Nature Reviews Neuroscience
JF - Nature Reviews Neuroscience
IS - 5
ER -