Novel approaches to bacterial infection therapy by interfering with bacteria-to-bacteria signaling

Research output: Contribution to journalReview articlepeer-review

35 Scopus citations

Abstract

The growing challenge of antimicrobial resistance and the paucity of novel antibiotics underscore the importance of developing novel therapeutics. Bacterial cell-to-cell signaling constitutes a novel drug target. Quorum sensing (QS) is a cell-to-cell signaling mechanism that refers to the ability of bacteria to respond to chemical hormone-like molecules called autoinducers. QS is responsible for controlling a plethora of virulence genes in several bacterial pathogens. Antagonists to autoinducers will intercept bacterial intercellular communication, hindering their ability to act in a coordinated manner to express virulence traits. Moreover, since QS is not involved directly in essential processes, such as bacterial growth, one can reason that inhibition of QS will not yield a selective pressure for the development of resistance.

Original languageEnglish (US)
Pages (from-to)271-276
Number of pages6
JournalExpert Review of Anti-Infective Therapy
Volume5
Issue number2
DOIs
StatePublished - Apr 2007

Keywords

  • Bacterial pathogenesis
  • EHEC
  • Enterohemorrhagic E. coli
  • Epinephrine
  • Quorum sensing

ASJC Scopus subject areas

  • Microbiology
  • Microbiology (medical)
  • Virology
  • Infectious Diseases

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