Novel biomarker candidates for colorectal cancer metastasis: A meta-analysis of in vitro studies

Nguyen Phuoc Long, Wun Jun Lee, Nguyen Truong Huy, Seul Ji Lee, Jeong Hill Park, Sung Won Kwon

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

Colorectal cancer (CRC) is one of the most common and lethal cancers. Although numerous studies have evaluated potential biomarkers for early diagnosis, current biomarkers have failed to reach an acceptable level of accuracy for distant metastasis. In this paper, we performed a gene set meta-analysis of in vitro microarray studies and combined the results from this study with previously published proteomic data to validate and suggest prog-nostic candidates for CRC metastasis. Two microarray data sets included found 21 significant genes. Of these significant genes, ALDOA, IL8 (CXCL8), and PARP4 had strong potential as prognostic candidates. LAMB2, MCM7, CXCL23A, SERPINA3, ABCA3, ALDH3A2, and POLR2I also have potential. Other candidates were more controversial, possibly because of the biologic heterogeneity of tumor cells, which is a major obstacle to predicting metastasis. In conclusion, we demonstrated a meta-analysis approach and successfully suggested ten biomarker candidates for future investigation.

Original languageEnglish (US)
Pages (from-to)11-17
Number of pages7
JournalCancer Informatics
Volume15
DOIs
StatePublished - Sep 22 2016

Keywords

  • Biomarker candidate
  • Colorectal cancer
  • Microarray analysis
  • Proteomics

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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  • Cite this

    Long, N. P., Lee, W. J., Huy, N. T., Lee, S. J., Park, J. H., & Kwon, S. W. (2016). Novel biomarker candidates for colorectal cancer metastasis: A meta-analysis of in vitro studies. Cancer Informatics, 15, 11-17. https://doi.org/10.4137/CIN.S40301