Novel epoxides formed during the liver cytochrome P-450 oxidation of arachidonic acid

N. Chacos, J R Falck, C. Wixtrom, J. Capdevila

Research output: Contribution to journalArticle

109 Scopus citations

Abstract

Arachidonic acid is enzymatically oxidized by the rat liver microsomal mixed-function oxidase system, in the presence of NADPH and oxygen, to a wide variety of products. We report here, the identification of the major organic-soluble metabolites. They are the 5,6-,8,9-,11,12-, and 14,15-epoxy-eicosatrienoic acid derivatives of arachidonic acid.

Original languageEnglish (US)
Pages (from-to)916-922
Number of pages7
JournalBiochemical and Biophysical Research Communications
Volume104
Issue number3
DOIs
StatePublished - Feb 11 1982

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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