Novel formation of 1,3-oxazepine heterocycles via palladium-catalyzed intramolecular coupling reaction

Chen Ma, Shao Jie Liu, Liang Xin, J. R. Falck, Dong Soo Shin

Research output: Contribution to journalArticle

21 Scopus citations

Abstract

The oxazepine ring systems containing pyridazinone moiety were constructed via palladium-catalyzed intramolecular coupling reaction. The best conditions for this reaction were Pd(OAc)2 as a palladium source, 1,1′-bis(diphenylphosphino)-ferrocene (DPPF) as the ligand, and K2CO3 as base at 80 °C in toluene. The products have potential applications as biological and medicinal relevant compounds.

Original languageEnglish (US)
Pages (from-to)9002-9009
Number of pages8
JournalTetrahedron
Volume62
Issue number38
DOIs
StatePublished - Sep 18 2006

    Fingerprint

Keywords

  • Intramolecular coupling
  • Oxazepine
  • Palladium catalyst
  • Synthesis

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

Cite this