Novel formation of 1,3-oxazepine heterocycles via palladium-catalyzed intramolecular coupling reaction

Chen Ma; Shao Jie Liu; Liang Xin; J. R. Falck; Dong Soo Shin

doi:10.1016/j.tet.2006.07.009

Novel formation of 1,3-oxazepine heterocycles via palladium-catalyzed intramolecular coupling reaction

Chen Ma, Shao Jie Liu, Liang Xin, J. R. Falck, Dong Soo Shin

Biochemistry

Research output: Contribution to journal › Article › peer-review

23 Scopus citations

Abstract

The oxazepine ring systems containing pyridazinone moiety were constructed via palladium-catalyzed intramolecular coupling reaction. The best conditions for this reaction were Pd(OAc)₂ as a palladium source, 1,1′-bis(diphenylphosphino)-ferrocene (DPPF) as the ligand, and K₂CO₃ as base at 80 °C in toluene. The products have potential applications as biological and medicinal relevant compounds.

Original language	English (US)
Pages (from-to)	9002-9009
Number of pages	8
Journal	Tetrahedron
Volume	62
Issue number	38
DOIs	https://doi.org/10.1016/j.tet.2006.07.009
State	Published - Sep 18 2006

Keywords

Intramolecular coupling
Oxazepine
Palladium catalyst
Synthesis

ASJC Scopus subject areas

Biochemistry
Drug Discovery
Organic Chemistry

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10.1016/j.tet.2006.07.009

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title = "Novel formation of 1,3-oxazepine heterocycles via palladium-catalyzed intramolecular coupling reaction",

abstract = "The oxazepine ring systems containing pyridazinone moiety were constructed via palladium-catalyzed intramolecular coupling reaction. The best conditions for this reaction were Pd(OAc)2 as a palladium source, 1,1′-bis(diphenylphosphino)-ferrocene (DPPF) as the ligand, and K2CO3 as base at 80 °C in toluene. The products have potential applications as biological and medicinal relevant compounds.",

keywords = "Intramolecular coupling, Oxazepine, Palladium catalyst, Synthesis",

author = "Chen Ma and Liu, {Shao Jie} and Liang Xin and Falck, {J. R.} and Shin, {Dong Soo}",

note = "Funding Information: The project was sponsored by the Scientific Research Foundation for the Returned Overseas Chinese Scholars, State Education Ministry (2004-527) and Excellent Young Scientist Awarded Foundation of Shandong Province (2005BS11007).",

year = "2006",

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TY - JOUR

T1 - Novel formation of 1,3-oxazepine heterocycles via palladium-catalyzed intramolecular coupling reaction

AU - Ma, Chen

AU - Liu, Shao Jie

AU - Xin, Liang

AU - Falck, J. R.

AU - Shin, Dong Soo

N1 - Funding Information: The project was sponsored by the Scientific Research Foundation for the Returned Overseas Chinese Scholars, State Education Ministry (2004-527) and Excellent Young Scientist Awarded Foundation of Shandong Province (2005BS11007).

PY - 2006/9/18

Y1 - 2006/9/18

N2 - The oxazepine ring systems containing pyridazinone moiety were constructed via palladium-catalyzed intramolecular coupling reaction. The best conditions for this reaction were Pd(OAc)2 as a palladium source, 1,1′-bis(diphenylphosphino)-ferrocene (DPPF) as the ligand, and K2CO3 as base at 80 °C in toluene. The products have potential applications as biological and medicinal relevant compounds.

AB - The oxazepine ring systems containing pyridazinone moiety were constructed via palladium-catalyzed intramolecular coupling reaction. The best conditions for this reaction were Pd(OAc)2 as a palladium source, 1,1′-bis(diphenylphosphino)-ferrocene (DPPF) as the ligand, and K2CO3 as base at 80 °C in toluene. The products have potential applications as biological and medicinal relevant compounds.

KW - Intramolecular coupling

KW - Oxazepine

KW - Palladium catalyst

KW - Synthesis

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DO - 10.1016/j.tet.2006.07.009

M3 - Article

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SN - 0040-4020

VL - 62

SP - 9002

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JO - Tetrahedron

JF - Tetrahedron

IS - 38

ER -

Novel formation of 1,3-oxazepine heterocycles via palladium-catalyzed intramolecular coupling reaction

Abstract

Keywords

ASJC Scopus subject areas

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