Novel insights into the pathogenesis of uric acid nephrolithiasis

Research output: Contribution to journalArticle

121 Citations (Scopus)

Abstract

Purpose of review: The factors involved in the pathogenesis of uric acid nephrolithiasis are well known. A low urinary pH is the most significant element in the generation of stones, with hyperuricosuria being a less common finding. The underlying mechanism(s) responsible for these disturbances remain poorly characterized. This review summarizes previous knowledge and highlights some recent developments in the pathophysiology of low urine pH and hyperuricosuria. Recent findings: Epidemiological and metabolic studies have indicated an association between uric acid nephrolithiasis and insulin resistance. Some potential mechanisms include impaired ammoniagenesis caused by resistance to insulin action in the renal proximal tubule, or substrate competition by free fatty acids. The evaluation of a large Sicilian kindred recently revealed a putative genetic locus linked to uric acid stone disease. The identification of novel complementary DNA has provided an interesting insight into the renal handling of uric acid, including one genetic cause of renal uric acid wasting. Summary: The recognition of metabolic, molecular, and genetic factors that influence urinary pH, and uric acid metabolism and excretion, will provide novel insights into the pathogenesis of uric acid stones, and open the way for new therapeutic strategies.

Original languageEnglish (US)
Pages (from-to)181-189
Number of pages9
JournalCurrent Opinion in Nephrology and Hypertension
Volume13
Issue number2
DOIs
StatePublished - Mar 2004

Fingerprint

Nephrolithiasis
Uric Acid
Insulin Resistance
Kidney
Proximal Kidney Tubule
Genetic Loci
Nonesterified Fatty Acids
Epidemiologic Studies
Molecular Biology
Complementary DNA
Urine

Keywords

  • Insulin resistance
  • Uric acid nephrolithiasis
  • Urine pH

ASJC Scopus subject areas

  • Nephrology
  • Internal Medicine

Cite this

Novel insights into the pathogenesis of uric acid nephrolithiasis. / Maalouf, Naim M.; Cameron, Mary Ann; Moe, Orson W.; Sakhaee, Khashayar.

In: Current Opinion in Nephrology and Hypertension, Vol. 13, No. 2, 03.2004, p. 181-189.

Research output: Contribution to journalArticle

@article{8e53a03848b044dfb1ec93e72ebda040,
title = "Novel insights into the pathogenesis of uric acid nephrolithiasis",
abstract = "Purpose of review: The factors involved in the pathogenesis of uric acid nephrolithiasis are well known. A low urinary pH is the most significant element in the generation of stones, with hyperuricosuria being a less common finding. The underlying mechanism(s) responsible for these disturbances remain poorly characterized. This review summarizes previous knowledge and highlights some recent developments in the pathophysiology of low urine pH and hyperuricosuria. Recent findings: Epidemiological and metabolic studies have indicated an association between uric acid nephrolithiasis and insulin resistance. Some potential mechanisms include impaired ammoniagenesis caused by resistance to insulin action in the renal proximal tubule, or substrate competition by free fatty acids. The evaluation of a large Sicilian kindred recently revealed a putative genetic locus linked to uric acid stone disease. The identification of novel complementary DNA has provided an interesting insight into the renal handling of uric acid, including one genetic cause of renal uric acid wasting. Summary: The recognition of metabolic, molecular, and genetic factors that influence urinary pH, and uric acid metabolism and excretion, will provide novel insights into the pathogenesis of uric acid stones, and open the way for new therapeutic strategies.",
keywords = "Insulin resistance, Uric acid nephrolithiasis, Urine pH",
author = "Maalouf, {Naim M.} and Cameron, {Mary Ann} and Moe, {Orson W.} and Khashayar Sakhaee",
year = "2004",
month = "3",
doi = "10.1097/00041552-200403000-00006",
language = "English (US)",
volume = "13",
pages = "181--189",
journal = "Current Opinion in Nephrology and Hypertension",
issn = "1062-4821",
publisher = "Lippincott Williams and Wilkins",
number = "2",

}

TY - JOUR

T1 - Novel insights into the pathogenesis of uric acid nephrolithiasis

AU - Maalouf, Naim M.

AU - Cameron, Mary Ann

AU - Moe, Orson W.

AU - Sakhaee, Khashayar

PY - 2004/3

Y1 - 2004/3

N2 - Purpose of review: The factors involved in the pathogenesis of uric acid nephrolithiasis are well known. A low urinary pH is the most significant element in the generation of stones, with hyperuricosuria being a less common finding. The underlying mechanism(s) responsible for these disturbances remain poorly characterized. This review summarizes previous knowledge and highlights some recent developments in the pathophysiology of low urine pH and hyperuricosuria. Recent findings: Epidemiological and metabolic studies have indicated an association between uric acid nephrolithiasis and insulin resistance. Some potential mechanisms include impaired ammoniagenesis caused by resistance to insulin action in the renal proximal tubule, or substrate competition by free fatty acids. The evaluation of a large Sicilian kindred recently revealed a putative genetic locus linked to uric acid stone disease. The identification of novel complementary DNA has provided an interesting insight into the renal handling of uric acid, including one genetic cause of renal uric acid wasting. Summary: The recognition of metabolic, molecular, and genetic factors that influence urinary pH, and uric acid metabolism and excretion, will provide novel insights into the pathogenesis of uric acid stones, and open the way for new therapeutic strategies.

AB - Purpose of review: The factors involved in the pathogenesis of uric acid nephrolithiasis are well known. A low urinary pH is the most significant element in the generation of stones, with hyperuricosuria being a less common finding. The underlying mechanism(s) responsible for these disturbances remain poorly characterized. This review summarizes previous knowledge and highlights some recent developments in the pathophysiology of low urine pH and hyperuricosuria. Recent findings: Epidemiological and metabolic studies have indicated an association between uric acid nephrolithiasis and insulin resistance. Some potential mechanisms include impaired ammoniagenesis caused by resistance to insulin action in the renal proximal tubule, or substrate competition by free fatty acids. The evaluation of a large Sicilian kindred recently revealed a putative genetic locus linked to uric acid stone disease. The identification of novel complementary DNA has provided an interesting insight into the renal handling of uric acid, including one genetic cause of renal uric acid wasting. Summary: The recognition of metabolic, molecular, and genetic factors that influence urinary pH, and uric acid metabolism and excretion, will provide novel insights into the pathogenesis of uric acid stones, and open the way for new therapeutic strategies.

KW - Insulin resistance

KW - Uric acid nephrolithiasis

KW - Urine pH

UR - http://www.scopus.com/inward/record.url?scp=1642365739&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=1642365739&partnerID=8YFLogxK

U2 - 10.1097/00041552-200403000-00006

DO - 10.1097/00041552-200403000-00006

M3 - Article

C2 - 15202612

AN - SCOPUS:1642365739

VL - 13

SP - 181

EP - 189

JO - Current Opinion in Nephrology and Hypertension

JF - Current Opinion in Nephrology and Hypertension

SN - 1062-4821

IS - 2

ER -