Novel JAK2 rearrangement resulting from a t(9;22)(p24;q11.2) in B-acute lymphoblastic leukemia

Carlos A. Tirado; Weina Chen; Lily Jun shen Huang; Carrie Laborde; Matthew C. Hiemenz; Federico Valdez; Kevin Ho; Naomi Winick; Zhenjun Lou; Prasad Koduru

doi:10.1016/j.leukres.2010.05.031

Novel JAK2 rearrangement resulting from a t(9;22)(p24;q11.2) in B-acute lymphoblastic leukemia

Carlos A. Tirado, Weina Chen, Lily Jun shen Huang, Carrie Laborde, Matthew C. Hiemenz, Federico Valdez, Kevin Ho, Naomi Winick, Zhenjun Lou, Prasad Koduru

Research output: Contribution to journal › Article › peer-review

20 Scopus citations

Abstract

Rearrangements of JAK2 are rare and have been described in various hematological neoplasms. We report a novel JAK2 rearrangement resulting from a t(9;22)(p24;q11.2) in a 14-year-old male with a diagnosis of B lymphoblastic leukemia. He was treated with Children's Oncology Group's protocol (AALL0232) but failed to achieve remission by day 29. He underwent a second induction and entered remission. His clinical course suggested that this JAK2 rearrangement might portend an unfavorable prognosis. This case brings the total number of JAK2 rearranged lymphoblastic leukemia cases in the literature to seven. The molecular genetic and clinicopathologic features of these cases were reviewed.

Original language	English (US)
Pages (from-to)	1674-1676
Number of pages	3
Journal	Leukemia Research
Volume	34
Issue number	12
DOIs	https://doi.org/10.1016/j.leukres.2010.05.031
State	Published - Dec 2010

Keywords

B-lymphoblastic leukemia
JAK2 rearrangement
T(9 ;22)(p24 ;q11.2)

ASJC Scopus subject areas

Hematology
Oncology
Cancer Research

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10.1016/j.leukres.2010.05.031

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title = "Novel JAK2 rearrangement resulting from a t(9;22)(p24;q11.2) in B-acute lymphoblastic leukemia",

abstract = "Rearrangements of JAK2 are rare and have been described in various hematological neoplasms. We report a novel JAK2 rearrangement resulting from a t(9;22)(p24;q11.2) in a 14-year-old male with a diagnosis of B lymphoblastic leukemia. He was treated with Children's Oncology Group's protocol (AALL0232) but failed to achieve remission by day 29. He underwent a second induction and entered remission. His clinical course suggested that this JAK2 rearrangement might portend an unfavorable prognosis. This case brings the total number of JAK2 rearranged lymphoblastic leukemia cases in the literature to seven. The molecular genetic and clinicopathologic features of these cases were reviewed.",

keywords = "B-lymphoblastic leukemia, JAK2 rearrangement, T(9 ;22)(p24 ;q11.2)",

author = "Tirado, {Carlos A.} and Weina Chen and Huang, {Lily Jun shen} and Carrie Laborde and Hiemenz, {Matthew C.} and Federico Valdez and Kevin Ho and Naomi Winick and Zhenjun Lou and Prasad Koduru",

year = "2010",

month = dec,

doi = "10.1016/j.leukres.2010.05.031",

language = "English (US)",

volume = "34",

pages = "1674--1676",

journal = "Leukemia Research",

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T1 - Novel JAK2 rearrangement resulting from a t(9;22)(p24;q11.2) in B-acute lymphoblastic leukemia

AU - Tirado, Carlos A.

AU - Chen, Weina

AU - Huang, Lily Jun shen

AU - Laborde, Carrie

AU - Hiemenz, Matthew C.

AU - Valdez, Federico

AU - Ho, Kevin

AU - Winick, Naomi

AU - Lou, Zhenjun

AU - Koduru, Prasad

PY - 2010/12

Y1 - 2010/12

N2 - Rearrangements of JAK2 are rare and have been described in various hematological neoplasms. We report a novel JAK2 rearrangement resulting from a t(9;22)(p24;q11.2) in a 14-year-old male with a diagnosis of B lymphoblastic leukemia. He was treated with Children's Oncology Group's protocol (AALL0232) but failed to achieve remission by day 29. He underwent a second induction and entered remission. His clinical course suggested that this JAK2 rearrangement might portend an unfavorable prognosis. This case brings the total number of JAK2 rearranged lymphoblastic leukemia cases in the literature to seven. The molecular genetic and clinicopathologic features of these cases were reviewed.

AB - Rearrangements of JAK2 are rare and have been described in various hematological neoplasms. We report a novel JAK2 rearrangement resulting from a t(9;22)(p24;q11.2) in a 14-year-old male with a diagnosis of B lymphoblastic leukemia. He was treated with Children's Oncology Group's protocol (AALL0232) but failed to achieve remission by day 29. He underwent a second induction and entered remission. His clinical course suggested that this JAK2 rearrangement might portend an unfavorable prognosis. This case brings the total number of JAK2 rearranged lymphoblastic leukemia cases in the literature to seven. The molecular genetic and clinicopathologic features of these cases were reviewed.

KW - B-lymphoblastic leukemia

KW - JAK2 rearrangement

KW - T(9 ;22)(p24 ;q11.2)

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Novel JAK2 rearrangement resulting from a t(9;22)(p24;q11.2) in B-acute lymphoblastic leukemia

Abstract

Keywords

ASJC Scopus subject areas

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