Novel JAK2 rearrangement resulting from a t(9;22)(p24;q11.2) in B-acute lymphoblastic leukemia

Carlos A. Tirado, Weina Chen, Lily Jun shen Huang, Carrie Laborde, Matthew C. Hiemenz, Federico Valdez, Kevin Ho, Naomi Winick, Zhenjun Lou, Prasad Koduru

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17 Scopus citations

Abstract

Rearrangements of JAK2 are rare and have been described in various hematological neoplasms. We report a novel JAK2 rearrangement resulting from a t(9;22)(p24;q11.2) in a 14-year-old male with a diagnosis of B lymphoblastic leukemia. He was treated with Children's Oncology Group's protocol (AALL0232) but failed to achieve remission by day 29. He underwent a second induction and entered remission. His clinical course suggested that this JAK2 rearrangement might portend an unfavorable prognosis. This case brings the total number of JAK2 rearranged lymphoblastic leukemia cases in the literature to seven. The molecular genetic and clinicopathologic features of these cases were reviewed.

Original languageEnglish (US)
Pages (from-to)1674-1676
Number of pages3
JournalLeukemia Research
Volume34
Issue number12
DOIs
StatePublished - Dec 1 2010

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Keywords

  • B-lymphoblastic leukemia
  • JAK2 rearrangement
  • T(9 ;22)(p24 ;q11.2)

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

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