Novel Lineage-Tracing System to Identify Site-Specific Ectopic Bone Precursor Cells

Chase A. Pagani, Amanda K. Huber, Charles Hwang, Simone Marini, Karthik Padmanabhan, Nicholas Livingston, Johanna Nunez, Yuxiao Sun, Nicole Edwards, Yu Hao Cheng, Noelle Visser, Pauline Yu, Nicole Patel, Joseph A. Greenstein, Husain Rasheed, Reagan Nelson, Karen Kessel, Kaetlin Vasquez, Amy L. Strong, Geoffrey E. HespeJane Y. Song, Deneen M. Wellik, Benjamin Levi

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Here, Pagani et al. use the Hoxa11 patterning gene, expressed exclusively in the limb zeugopod, to demonstrate by bioinformatic single cell transcriptomic, epigenomic analyses, and ex vivo confocal microscopy that extra-skeletal cells originating from Hoxa11 lineage cells are a population of mesenchymal cells with the ability to undergo aberrant differentiation towards chondrocytes, osteoblasts or adipocytes after injury

Original languageEnglish (US)
Pages (from-to)626-640
Number of pages15
JournalStem Cell Reports
Volume16
Issue number3
DOIs
StatePublished - Mar 9 2021

Keywords

  • Hoxa11
  • aberrant differentiation
  • heterotopic ossification
  • mesenchymal progenitors
  • tendon

ASJC Scopus subject areas

  • Biochemistry
  • Genetics
  • Developmental Biology
  • Cell Biology

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