Novel molecular probes for 19F magnetic resonance imaging

synthesis & characterization of fluorinated polymers

V. D. Mehta, P. V. Kulkarni, R. P. Mason, E. E. Babcock, A. Constantinescu, P. P. Antich

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Fluorine labelled polymers have been synthesized and characterized to investigate vascular phenomena in vivo with 19F Magnetic Resonance Imaging (MRI). The polymers have molecular weights in the range 10 k to 98 k and include polylysines and functionalized dextrans (polyamino dextrans and polyaldehyde dextrans). These fluorinated polymers exhibit a single sharp 19F signal, appropriate 19F MR detection sensitivity, and the biocompatibility necessary for in vivo MRI.

Original languageEnglish (US)
Pages (from-to)527-532
Number of pages6
JournalBioorganic and Medicinal Chemistry Letters
Volume2
Issue number6
DOIs
StatePublished - 1992

Fingerprint

Fluorocarbon Polymers
Molecular Probes
Magnetic resonance
Dextrans
Polymers
Magnetic Resonance Imaging
Imaging techniques
Polylysine
Dextran
Fluorine
Biocompatibility
Blood Vessels
Molecular Weight
Molecular weight

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Organic Chemistry
  • Drug Discovery
  • Pharmaceutical Science

Cite this

Novel molecular probes for 19F magnetic resonance imaging : synthesis & characterization of fluorinated polymers. / Mehta, V. D.; Kulkarni, P. V.; Mason, R. P.; Babcock, E. E.; Constantinescu, A.; Antich, P. P.

In: Bioorganic and Medicinal Chemistry Letters, Vol. 2, No. 6, 1992, p. 527-532.

Research output: Contribution to journalArticle

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