Novel molecular probes for 19F magnetic resonance imaging: synthesis & characterization of fluorinated polymers

V. D. Mehta; P. V. Kulkarni; R. P. Mason; E. E. Babcock; A. Constantinescu; P. P. Antich

doi:10.1016/S0960-894X(01)81191-4

Novel molecular probes for ¹⁹F magnetic resonance imaging: synthesis & characterization of fluorinated polymers

V. D. Mehta, P. V. Kulkarni, R. P. Mason, E. E. Babcock, A. Constantinescu, P. P. Antich

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

Fluorine labelled polymers have been synthesized and characterized to investigate vascular phenomena in vivo with ¹⁹F Magnetic Resonance Imaging (MRI). The polymers have molecular weights in the range 10 k to 98 k and include polylysines and functionalized dextrans (polyamino dextrans and polyaldehyde dextrans). These fluorinated polymers exhibit a single sharp ¹⁹F signal, appropriate ¹⁹F MR detection sensitivity, and the biocompatibility necessary for in vivo MRI.

Original language	English (US)
Pages (from-to)	527-532
Number of pages	6
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	2
Issue number	6
DOIs	https://doi.org/10.1016/S0960-894X(01)81191-4
State	Published - Jun 1992

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

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title = "Novel molecular probes for 19F magnetic resonance imaging: synthesis & characterization of fluorinated polymers",

abstract = "Fluorine labelled polymers have been synthesized and characterized to investigate vascular phenomena in vivo with 19F Magnetic Resonance Imaging (MRI). The polymers have molecular weights in the range 10 k to 98 k and include polylysines and functionalized dextrans (polyamino dextrans and polyaldehyde dextrans). These fluorinated polymers exhibit a single sharp 19F signal, appropriate 19F MR detection sensitivity, and the biocompatibility necessary for in vivo MRI.",

author = "Mehta, {V. D.} and Kulkarni, {P. V.} and Mason, {R. P.} and Babcock, {E. E.} and A. Constantinescu and Antich, {P. P.}",

year = "1992",

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T1 - Novel molecular probes for 19F magnetic resonance imaging

T2 - synthesis & characterization of fluorinated polymers

AU - Mehta, V. D.

AU - Kulkarni, P. V.

AU - Mason, R. P.

AU - Babcock, E. E.

AU - Constantinescu, A.

AU - Antich, P. P.

PY - 1992/6

Y1 - 1992/6

N2 - Fluorine labelled polymers have been synthesized and characterized to investigate vascular phenomena in vivo with 19F Magnetic Resonance Imaging (MRI). The polymers have molecular weights in the range 10 k to 98 k and include polylysines and functionalized dextrans (polyamino dextrans and polyaldehyde dextrans). These fluorinated polymers exhibit a single sharp 19F signal, appropriate 19F MR detection sensitivity, and the biocompatibility necessary for in vivo MRI.

AB - Fluorine labelled polymers have been synthesized and characterized to investigate vascular phenomena in vivo with 19F Magnetic Resonance Imaging (MRI). The polymers have molecular weights in the range 10 k to 98 k and include polylysines and functionalized dextrans (polyamino dextrans and polyaldehyde dextrans). These fluorinated polymers exhibit a single sharp 19F signal, appropriate 19F MR detection sensitivity, and the biocompatibility necessary for in vivo MRI.

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ER -

Novel molecular probes for ¹⁹F magnetic resonance imaging: synthesis & characterization of fluorinated polymers

Abstract

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