Novel molecular probes for 19F magnetic resonance imaging: synthesis & characterization of fluorinated polymers

V. D. Mehta, P. V. Kulkarni, R. P. Mason, E. E. Babcock, A. Constantinescu, P. P. Antich

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

Fluorine labelled polymers have been synthesized and characterized to investigate vascular phenomena in vivo with 19F Magnetic Resonance Imaging (MRI). The polymers have molecular weights in the range 10 k to 98 k and include polylysines and functionalized dextrans (polyamino dextrans and polyaldehyde dextrans). These fluorinated polymers exhibit a single sharp 19F signal, appropriate 19F MR detection sensitivity, and the biocompatibility necessary for in vivo MRI.

Original languageEnglish (US)
Pages (from-to)527-532
Number of pages6
JournalBioorganic and Medicinal Chemistry Letters
Volume2
Issue number6
DOIs
StatePublished - Jun 1992

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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