Novel players in inflammatory bowel disease pathogenesis

Stephen F. Murphy, John H. Kwon, David L. Boone

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Technological and conceptual advances in inflammatory bowel disease research have uncovered new mechanisms that contribute to the pathogenesis of these disorders. It is becoming increasingly clear that the microbiota of the gut and the response of intestinal cells to that microbiota can initiate or contribute to intestinal inflammation. Evidence from genetic studies have identified IBDassociated genes implicated in autophagy and innate sensing of microbes. These genes also play key roles in the homeostasis of a cell type that stands at the interface of host-microbial interaction - the Paneth cell. Here we discuss recent findings that underscore the importance of the microbiome, Paneth cells and autophagy in inflammatory bowel disease.

Original languageEnglish (US)
Pages (from-to)146-152
Number of pages7
JournalCurrent Gastroenterology Reports
Volume14
Issue number2
DOIs
StatePublished - Apr 1 2012

Fingerprint

Paneth Cells
Microbiota
Autophagy
Inflammatory Bowel Diseases
Microbial Interactions
Genes
Homeostasis
Inflammation
Research
Gastrointestinal Microbiome

Keywords

  • ATG16L1
  • Autophagy
  • Crohn's disease
  • ER Stress
  • IRGM
  • Microbiome
  • NOD2
  • Novel regulator pathways
  • Paneth cell
  • Ulcerative colitis
  • Unfolded protein response

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Novel players in inflammatory bowel disease pathogenesis. / Murphy, Stephen F.; Kwon, John H.; Boone, David L.

In: Current Gastroenterology Reports, Vol. 14, No. 2, 01.04.2012, p. 146-152.

Research output: Contribution to journalArticle

Murphy, Stephen F. ; Kwon, John H. ; Boone, David L. / Novel players in inflammatory bowel disease pathogenesis. In: Current Gastroenterology Reports. 2012 ; Vol. 14, No. 2. pp. 146-152.
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