Novel putative receptor tyrosine kinase encoded by the melanoma-inducing Tu locus in Xiphophorus

Joachim Wittbrodt, Dieter Adam, Barbara Malitschek, Winfried Mäueler, Friedrich Raulf, Agnes Telling, Scott M. Robertson, Manfred Schartl

Research output: Contribution to journalArticle

246 Citations (Scopus)

Abstract

Malignant melanoma in Xiphophorus fish hybrids is caused by the activity of a dominant oncogene Tu. By combining genetic and molecular approaches, we have isolated the melanoma oncogene. We show that its level of expression correlates with the degree of malignancy of the tumour. The corresponding proto-oncogene is developmentally regulated. The Tu gene codes for a novel receptor tyrosine kinase which is closely related to the receptor for epidermal growth factor.

Original languageEnglish (US)
Pages (from-to)415-421
Number of pages7
JournalNature
Volume341
Issue number6241
StatePublished - 1989

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Cyprinodontiformes
Receptor Protein-Tyrosine Kinases
Oncogenes
Melanoma
Proto-Oncogenes
Epidermal Growth Factor Receptor
Molecular Biology
Neoplasms
Fishes
Genes

ASJC Scopus subject areas

  • General

Cite this

Wittbrodt, J., Adam, D., Malitschek, B., Mäueler, W., Raulf, F., Telling, A., ... Schartl, M. (1989). Novel putative receptor tyrosine kinase encoded by the melanoma-inducing Tu locus in Xiphophorus. Nature, 341(6241), 415-421.

Novel putative receptor tyrosine kinase encoded by the melanoma-inducing Tu locus in Xiphophorus. / Wittbrodt, Joachim; Adam, Dieter; Malitschek, Barbara; Mäueler, Winfried; Raulf, Friedrich; Telling, Agnes; Robertson, Scott M.; Schartl, Manfred.

In: Nature, Vol. 341, No. 6241, 1989, p. 415-421.

Research output: Contribution to journalArticle

Wittbrodt, J, Adam, D, Malitschek, B, Mäueler, W, Raulf, F, Telling, A, Robertson, SM & Schartl, M 1989, 'Novel putative receptor tyrosine kinase encoded by the melanoma-inducing Tu locus in Xiphophorus', Nature, vol. 341, no. 6241, pp. 415-421.
Wittbrodt J, Adam D, Malitschek B, Mäueler W, Raulf F, Telling A et al. Novel putative receptor tyrosine kinase encoded by the melanoma-inducing Tu locus in Xiphophorus. Nature. 1989;341(6241):415-421.
Wittbrodt, Joachim ; Adam, Dieter ; Malitschek, Barbara ; Mäueler, Winfried ; Raulf, Friedrich ; Telling, Agnes ; Robertson, Scott M. ; Schartl, Manfred. / Novel putative receptor tyrosine kinase encoded by the melanoma-inducing Tu locus in Xiphophorus. In: Nature. 1989 ; Vol. 341, No. 6241. pp. 415-421.
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