Novel recurrently mutated genes in African American colon cancers

Kishore Guda, Martina L. Veigl, Vinay Varadan, Arman Nosrati, Lakshmeswari Ravi, James Lutterbaugh, Lydia Beard, James K V Willson, W. David Sedwick, Zhenghe John Wang, Neil Molyneaux, Alexander Miron, Mark D. Adams, Robert C. Elston, Sanford D. Markowitz, Joseph E. Willis

Research output: Contribution to journalArticle

41 Citations (Scopus)

Abstract

We used whole-exome and targeted sequencing to characterize somatic mutations in 103 colorectal cancers (CRC) from African Americans, identifying 20 new genes as significantly mutated in CRC. Resequencing 129 Caucasian derived CRCs confirmed a 15-gene set as a preferential target for mutations in African American CRCs. Two predominant genes, ephrin type A receptor 6 (EPHA6) and folliculin (FLCN), with mutations exclusive to African American CRCs, are by genetic and biological criteria highly likely African American CRC driver genes. These previously unsuspected differences in the mutational landscapes of CRCs arising among individuals of different ethnicities have potential to impact on broader disparities in cancer behaviors.

Original languageEnglish (US)
Pages (from-to)1149-1154
Number of pages6
JournalProceedings of the National Academy of Sciences of the United States of America
Volume112
Issue number4
DOIs
StatePublished - Jan 27 2015

Fingerprint

African Americans
Colonic Neoplasms
Colorectal Neoplasms
Mutation
Genes
Eph Family Receptors
Exome
Estrone
Neoplasm Genes
Neoplasms

Keywords

  • African american
  • Caucasian
  • Colon cancer
  • Mutation
  • Next-generation sequencing

ASJC Scopus subject areas

  • General

Cite this

Guda, K., Veigl, M. L., Varadan, V., Nosrati, A., Ravi, L., Lutterbaugh, J., ... Willis, J. E. (2015). Novel recurrently mutated genes in African American colon cancers. Proceedings of the National Academy of Sciences of the United States of America, 112(4), 1149-1154. https://doi.org/10.1073/pnas.1417064112

Novel recurrently mutated genes in African American colon cancers. / Guda, Kishore; Veigl, Martina L.; Varadan, Vinay; Nosrati, Arman; Ravi, Lakshmeswari; Lutterbaugh, James; Beard, Lydia; Willson, James K V; Sedwick, W. David; Wang, Zhenghe John; Molyneaux, Neil; Miron, Alexander; Adams, Mark D.; Elston, Robert C.; Markowitz, Sanford D.; Willis, Joseph E.

In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 112, No. 4, 27.01.2015, p. 1149-1154.

Research output: Contribution to journalArticle

Guda, K, Veigl, ML, Varadan, V, Nosrati, A, Ravi, L, Lutterbaugh, J, Beard, L, Willson, JKV, Sedwick, WD, Wang, ZJ, Molyneaux, N, Miron, A, Adams, MD, Elston, RC, Markowitz, SD & Willis, JE 2015, 'Novel recurrently mutated genes in African American colon cancers', Proceedings of the National Academy of Sciences of the United States of America, vol. 112, no. 4, pp. 1149-1154. https://doi.org/10.1073/pnas.1417064112
Guda, Kishore ; Veigl, Martina L. ; Varadan, Vinay ; Nosrati, Arman ; Ravi, Lakshmeswari ; Lutterbaugh, James ; Beard, Lydia ; Willson, James K V ; Sedwick, W. David ; Wang, Zhenghe John ; Molyneaux, Neil ; Miron, Alexander ; Adams, Mark D. ; Elston, Robert C. ; Markowitz, Sanford D. ; Willis, Joseph E. / Novel recurrently mutated genes in African American colon cancers. In: Proceedings of the National Academy of Sciences of the United States of America. 2015 ; Vol. 112, No. 4. pp. 1149-1154.
@article{11c9d54c8c174ef5b3e4e8fd24c2e3eb,
title = "Novel recurrently mutated genes in African American colon cancers",
abstract = "We used whole-exome and targeted sequencing to characterize somatic mutations in 103 colorectal cancers (CRC) from African Americans, identifying 20 new genes as significantly mutated in CRC. Resequencing 129 Caucasian derived CRCs confirmed a 15-gene set as a preferential target for mutations in African American CRCs. Two predominant genes, ephrin type A receptor 6 (EPHA6) and folliculin (FLCN), with mutations exclusive to African American CRCs, are by genetic and biological criteria highly likely African American CRC driver genes. These previously unsuspected differences in the mutational landscapes of CRCs arising among individuals of different ethnicities have potential to impact on broader disparities in cancer behaviors.",
keywords = "African american, Caucasian, Colon cancer, Mutation, Next-generation sequencing",
author = "Kishore Guda and Veigl, {Martina L.} and Vinay Varadan and Arman Nosrati and Lakshmeswari Ravi and James Lutterbaugh and Lydia Beard and Willson, {James K V} and Sedwick, {W. David} and Wang, {Zhenghe John} and Neil Molyneaux and Alexander Miron and Adams, {Mark D.} and Elston, {Robert C.} and Markowitz, {Sanford D.} and Willis, {Joseph E.}",
year = "2015",
month = "1",
day = "27",
doi = "10.1073/pnas.1417064112",
language = "English (US)",
volume = "112",
pages = "1149--1154",
journal = "Proceedings of the National Academy of Sciences of the United States of America",
issn = "0027-8424",
number = "4",

}

TY - JOUR

T1 - Novel recurrently mutated genes in African American colon cancers

AU - Guda, Kishore

AU - Veigl, Martina L.

AU - Varadan, Vinay

AU - Nosrati, Arman

AU - Ravi, Lakshmeswari

AU - Lutterbaugh, James

AU - Beard, Lydia

AU - Willson, James K V

AU - Sedwick, W. David

AU - Wang, Zhenghe John

AU - Molyneaux, Neil

AU - Miron, Alexander

AU - Adams, Mark D.

AU - Elston, Robert C.

AU - Markowitz, Sanford D.

AU - Willis, Joseph E.

PY - 2015/1/27

Y1 - 2015/1/27

N2 - We used whole-exome and targeted sequencing to characterize somatic mutations in 103 colorectal cancers (CRC) from African Americans, identifying 20 new genes as significantly mutated in CRC. Resequencing 129 Caucasian derived CRCs confirmed a 15-gene set as a preferential target for mutations in African American CRCs. Two predominant genes, ephrin type A receptor 6 (EPHA6) and folliculin (FLCN), with mutations exclusive to African American CRCs, are by genetic and biological criteria highly likely African American CRC driver genes. These previously unsuspected differences in the mutational landscapes of CRCs arising among individuals of different ethnicities have potential to impact on broader disparities in cancer behaviors.

AB - We used whole-exome and targeted sequencing to characterize somatic mutations in 103 colorectal cancers (CRC) from African Americans, identifying 20 new genes as significantly mutated in CRC. Resequencing 129 Caucasian derived CRCs confirmed a 15-gene set as a preferential target for mutations in African American CRCs. Two predominant genes, ephrin type A receptor 6 (EPHA6) and folliculin (FLCN), with mutations exclusive to African American CRCs, are by genetic and biological criteria highly likely African American CRC driver genes. These previously unsuspected differences in the mutational landscapes of CRCs arising among individuals of different ethnicities have potential to impact on broader disparities in cancer behaviors.

KW - African american

KW - Caucasian

KW - Colon cancer

KW - Mutation

KW - Next-generation sequencing

UR - http://www.scopus.com/inward/record.url?scp=84921773896&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84921773896&partnerID=8YFLogxK

U2 - 10.1073/pnas.1417064112

DO - 10.1073/pnas.1417064112

M3 - Article

VL - 112

SP - 1149

EP - 1154

JO - Proceedings of the National Academy of Sciences of the United States of America

JF - Proceedings of the National Academy of Sciences of the United States of America

SN - 0027-8424

IS - 4

ER -