Abstract
A novel and effective synthesis of pyridazino[4,5-b][1,4]oxazin-3,8-diones via Smiles rearrangement is presented. Treatment of N-substituted 2-chloro(or hydroxy)acetamide, 2-tetrahydropyranyl-4-chloro-5-hydroxy(or chloro)pyridazin-3-one and cesium carbonate in refluxing acetonitrile was afforded the corresponding pyridazino[4,5-b][1,4]oxazin-3,8-diones in excellent yield.
Original language | English (US) |
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Pages (from-to) | 8995-8998 |
Number of pages | 4 |
Journal | Tetrahedron Letters |
Volume | 44 |
Issue number | 50 |
DOIs | |
State | Published - Dec 8 2003 |
Keywords
- Pyrodazino[4,5-b][1,4]oxazine
- Smiles rearrangement
ASJC Scopus subject areas
- Biochemistry
- Drug Discovery
- Organic Chemistry