Novel technique for characterizing prostate cancer utilizing MRI restriction spectrum imaging: Proof of principle and initial clinical experience with extraprostatic extension

R. A. Rakow-Penner, N. S. White, J. K. Parsons, H. W. Choi, M. A. Liss, J. M. Kuperman, N. Schenker-Ahmed, H. Bartsch, R. F. Mattrey, W. G. Bradley, A. Shabaik, J. Huang, D. J.A. Margolis, S. S. Raman, L. Marks, C. J. Kane, R. E. Reiter, D. S. Karow, A. M. Dale

Research output: Contribution to journalArticle

18 Scopus citations

Abstract

BACKGROUND: Standard magnetic resonance imaging (MRI) of the prostate lacks sensitivity in the diagnosis and staging of prostate cancer (PCa). To improve the operating characteristics of prostate MRI in the detection and characterization of PCa, we developed a novel, enhanced MRI diffusion technique using restriction spectrum imaging (RSI-MRI). METHODS: We compared the ef ficacy of our novel RSI-MRI technique with standard MRI for detecting extraprostatic extension (EPE) among 28 PCa patients who underwent MRI and RSI-MRI prior to radical prostatectomy, 10 with histologically proven pT3 disease. RSI cellularity maps isolating the restricted isotropic water fraction were reconstructed based on all b-values and then standardized across the sample with z-score maps. Distortion correction of the RSI maps was performed using the alternating phase-encode technique. RESULTS: 27 patients were evaluated, excluding one patient where distortion could not be performed. Preoperative standard MRI correctly identified extraprostatic the extension in two of the nine pT3 (22%) patients, whereas RSI-MRI identi fied EPE in eight of nine (89%) patients. RSI-MRI correctly identified pT2 disease in the remaining 18 patients. CONCLUSIONS: In this proof of principle study, we conclude that our novel RSI-MRI technology is feasible and shows promise for substantially improving PCa imaging. Further translational studies of prostate RSI-MRI in the diagnosis and staging of PCa are indicated.

Original languageEnglish (US)
Pages (from-to)81-85
Number of pages5
JournalProstate Cancer and Prostatic Diseases
Volume18
Issue number1
DOIs
StatePublished - Mar 11 2015

ASJC Scopus subject areas

  • Oncology
  • Urology
  • Cancer Research

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    Rakow-Penner, R. A., White, N. S., Parsons, J. K., Choi, H. W., Liss, M. A., Kuperman, J. M., Schenker-Ahmed, N., Bartsch, H., Mattrey, R. F., Bradley, W. G., Shabaik, A., Huang, J., Margolis, D. J. A., Raman, S. S., Marks, L., Kane, C. J., Reiter, R. E., Karow, D. S., & Dale, A. M. (2015). Novel technique for characterizing prostate cancer utilizing MRI restriction spectrum imaging: Proof of principle and initial clinical experience with extraprostatic extension. Prostate Cancer and Prostatic Diseases, 18(1), 81-85. https://doi.org/10.1038/pcan.2014.50