Nuclear imprisonment: Viral strategies to arrest host mRNA nuclear export

Sharon K. Kuss, Miguel A. Mata, Liang Zhang, Beatriz M A Fontoura

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

Viruses possess many strategies to impair host cellular responses to infection. Nuclear export of host messenger RNAs (mRNA) that encode antiviral factors is critical for antiviral protein production and control of viral infections. Several viruses have evolved sophisticated strategies to inhibit nuclear export of host mRNAs, including targeting mRNA export factors and nucleoporins to compromise their roles in nucleo-cytoplasmic trafficking of cellular mRNA. Here, we present a review of research focused on suppression of host mRNA nuclear export by viruses, including influenza A virus and vesicular stomatitis virus, and the impact of this viral suppression on host antiviral responses.

Original languageEnglish (US)
Pages (from-to)1824-1849
Number of pages26
JournalViruses
Volume5
Issue number7
DOIs
StatePublished - Jul 18 2013

Fingerprint

Cell Nucleus Active Transport
Messenger RNA
Viruses
Antiviral Agents
Nuclear Pore Complex Proteins
Vesicular Stomatitis
Influenza A virus
Virus Diseases
Infection
Research
Proteins

Keywords

  • CRM1
  • Influenza virus
  • Matrix protein
  • mRNA export
  • NS1
  • Nuclear export
  • Nucleo-cytoplasmic trafficking
  • NXF1
  • Rae1
  • TAP
  • Vesicular stomatitis virus
  • Virus
  • VSV

ASJC Scopus subject areas

  • Infectious Diseases
  • Virology

Cite this

Nuclear imprisonment : Viral strategies to arrest host mRNA nuclear export. / Kuss, Sharon K.; Mata, Miguel A.; Zhang, Liang; Fontoura, Beatriz M A.

In: Viruses, Vol. 5, No. 7, 18.07.2013, p. 1824-1849.

Research output: Contribution to journalArticle

Kuss, Sharon K. ; Mata, Miguel A. ; Zhang, Liang ; Fontoura, Beatriz M A. / Nuclear imprisonment : Viral strategies to arrest host mRNA nuclear export. In: Viruses. 2013 ; Vol. 5, No. 7. pp. 1824-1849.
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