Nuclear receptor-dependent transcription with chromatin. Is it all about enzymes?

W. Lee Kraus, Jiemin Wong

Research output: Contribution to journalArticle

63 Citations (Scopus)

Abstract

Nuclear receptors (NRs) are ligand-regulated, DNA-binding transcription factors that function in the chromatin environment of the nucleus to alter the expression of subsets of hormone-responsive genes. It is clear that chromatin, rather than being a passive player, has a profound effect on both transcriptional repression and activation mediated by NRs. NRs act in conjunction with at least three general classes of cofactors to regulate transcription in the context of chromatin: (a) chromatin remodelers; (b) corepressors; and (c) coactivators, many of which have distinct enzymatic activities that remodel nucleosomes or covalently modify histones (e.g. acetylases, deacetylases, methyltransferases, and kinases). In this paper, we will present a brief overview of these enzymes, their activities, and how they assist NRs in the repression or activation of transcription in the context of chromatin.

Original languageEnglish (US)
Pages (from-to)2275-2283
Number of pages9
JournalEuropean Journal of Biochemistry
Volume269
Issue number9
DOIs
StatePublished - 2002

Fingerprint

Transcription
Cytoplasmic and Nuclear Receptors
Chromatin
Enzymes
Transcriptional Activation
Chemical activation
Acetylesterase
Histone Acetyltransferases
Co-Repressor Proteins
Nucleosomes
Methyltransferases
Enzyme activity
Histones
Transcription Factors
Phosphotransferases
Genes
Hormones
Ligands
DNA

Keywords

  • Chromatin
  • Chromatin remodeling
  • Coactivators
  • Corepressors
  • Histone acetyltransferase
  • Histone deacetylase
  • Histone kinase
  • Histone methyltransferase
  • Nuclear receptor
  • Transcription

ASJC Scopus subject areas

  • Biochemistry

Cite this

Nuclear receptor-dependent transcription with chromatin. Is it all about enzymes? / Kraus, W. Lee; Wong, Jiemin.

In: European Journal of Biochemistry, Vol. 269, No. 9, 2002, p. 2275-2283.

Research output: Contribution to journalArticle

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