TY - JOUR
T1 - Nuclear Receptor Expression Links the Circadian Clock to Metabolism
AU - Yang, Xiaoyong
AU - Downes, Michael
AU - Yu, Ruth T.
AU - Bookout, Angie L.
AU - He, Weimin
AU - Straume, Marty
AU - Mangelsdorf, David J.
AU - Evans, Ronald M.
N1 - Funding Information:
We thank Drs. Neil McKenna, Rainer Lanz and the entire Bioinformatics Core at Baylor for their expertise in data analyses and presentation for the NURSA website. We also thank Drs. Satchin Panda, Vincent Giguere, and Grant Barish for critical reading of the manuscript. We thank I. Mehl and P. Olson for reagents; M. Nelson and J. Havstad for technical help; and E. Stevens and L. Ong for administrative assistance. X.Y. was supported by the American Cancer Society Postdoctoral Fellowship. D.J.M. and R.M.E. are Investigators of the Howard Hughes Medical Institute. R.M.E. is the March of Dimes Chair in Molecular and Developmental Biology. This work was supported by the Howard Hughes Medical Institute, the NIH (Atlas grant #U19DK62434-01), and the Robert A. Welch Foundation (#I-1275).
PY - 2006/8/25
Y1 - 2006/8/25
N2 - As sensors for fat-soluble hormones and dietary lipids, oscillations in nuclear receptor (NR) expression in key metabolic tissues may contribute to circadian entrainment of nutrient and energy metabolism. Surveying the diurnal expression profiles of all 49 mouse nuclear receptors in white and brown adipose tissue, liver, and skeletal muscle revealed that of the 45 NRs expressed, 25 are in a rhythmic cycle and 3 exhibit a single transient pulse of expression 4 hr into the light cycle. While thyroid hormones are generally constant, we find that TRα and β dramatically cycle, suggesting that fundamental concepts such as "basal metabolism" may require reexamination. The dynamic but coordinated changes in nuclear receptor expression, along with their key target genes, offers a logical explanation for known cyclic behavior of lipid and glucose metabolism and suggests novel roles for endocrine and orphan receptors in coupling the peripheral circadian clock to divergent metabolic outputs.
AB - As sensors for fat-soluble hormones and dietary lipids, oscillations in nuclear receptor (NR) expression in key metabolic tissues may contribute to circadian entrainment of nutrient and energy metabolism. Surveying the diurnal expression profiles of all 49 mouse nuclear receptors in white and brown adipose tissue, liver, and skeletal muscle revealed that of the 45 NRs expressed, 25 are in a rhythmic cycle and 3 exhibit a single transient pulse of expression 4 hr into the light cycle. While thyroid hormones are generally constant, we find that TRα and β dramatically cycle, suggesting that fundamental concepts such as "basal metabolism" may require reexamination. The dynamic but coordinated changes in nuclear receptor expression, along with their key target genes, offers a logical explanation for known cyclic behavior of lipid and glucose metabolism and suggests novel roles for endocrine and orphan receptors in coupling the peripheral circadian clock to divergent metabolic outputs.
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U2 - 10.1016/j.cell.2006.06.050
DO - 10.1016/j.cell.2006.06.050
M3 - Article
C2 - 16923398
AN - SCOPUS:33747157406
SN - 0092-8674
VL - 126
SP - 801
EP - 810
JO - Cell
JF - Cell
IS - 4
ER -