Nuclear receptor regulation of cholesterol and bile acid metabolism

Research output: Contribution to journalReview articlepeer-review

165 Scopus citations


The metabolism of cholesterol and bile acids is transcriptionally regulated by classic feedforward and feedback signaling pathways. The mechanisms underlying this regulation have recently been elucidated by the characterization of three classes of orphan nuclear receptors. Furthermore, the study of these receptors suggests their potential as targets for new drug therapies.

Original languageEnglish (US)
Pages (from-to)557-563
Number of pages7
JournalCurrent Opinion in Biotechnology
Issue number6
StatePublished - Dec 1 1999

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering
  • Biomedical Engineering


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