Nuclear receptor that identifies a novel retinoic acid response pathway

David J. Mangelsdorf; Estelita S. Ong; Jacqueline A. Dyck; Ronald M. Evans

doi:10.1038/345224a0

Nuclear receptor that identifies a novel retinoic acid response pathway

David J. Mangelsdorf, Estelita S. Ong, Jacqueline A. Dyck, Ronald M. Evans

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Abstract

Molecular cloning and transcriptional activation studies have revealed a new protein similar to the steroid hormone receptors and which responds specifically to vitamin A metabolites. This protein is substantially different in primary structure and ligand specificity from the products of the previously described retinoic acid receptor gene family. By indicating the existence of an additional pathway through which retinoic acid may exert its effects, these data lead to a re-evaluation of retinoid physiology.

Original language	English (US)
Pages (from-to)	224-229
Number of pages	6
Journal	Nature
Volume	345
Issue number	6272
DOIs	https://doi.org/10.1038/345224a0
State	Published - 1990

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title = "Nuclear receptor that identifies a novel retinoic acid response pathway",

abstract = "Molecular cloning and transcriptional activation studies have revealed a new protein similar to the steroid hormone receptors and which responds specifically to vitamin A metabolites. This protein is substantially different in primary structure and ligand specificity from the products of the previously described retinoic acid receptor gene family. By indicating the existence of an additional pathway through which retinoic acid may exert its effects, these data lead to a re-evaluation of retinoid physiology.",

author = "Mangelsdorf, {David J.} and Ong, {Estelita S.} and Dyck, {Jacqueline A.} and Evans, {Ronald M.}",

year = "1990",

doi = "10.1038/345224a0",

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journal = "Nature",

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T1 - Nuclear receptor that identifies a novel retinoic acid response pathway

AU - Mangelsdorf, David J.

AU - Ong, Estelita S.

AU - Dyck, Jacqueline A.

AU - Evans, Ronald M.

PY - 1990

Y1 - 1990

N2 - Molecular cloning and transcriptional activation studies have revealed a new protein similar to the steroid hormone receptors and which responds specifically to vitamin A metabolites. This protein is substantially different in primary structure and ligand specificity from the products of the previously described retinoic acid receptor gene family. By indicating the existence of an additional pathway through which retinoic acid may exert its effects, these data lead to a re-evaluation of retinoid physiology.

AB - Molecular cloning and transcriptional activation studies have revealed a new protein similar to the steroid hormone receptors and which responds specifically to vitamin A metabolites. This protein is substantially different in primary structure and ligand specificity from the products of the previously described retinoic acid receptor gene family. By indicating the existence of an additional pathway through which retinoic acid may exert its effects, these data lead to a re-evaluation of retinoid physiology.

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Nuclear receptor that identifies a novel retinoic acid response pathway

Abstract

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