Nuclear receptor that identifies a novel retinoic acid response pathway

David J. Mangelsdorf, Estelita S. Ong, Jacqueline A. Dyck, Ronald M. Evans

Research output: Contribution to journalArticle

1168 Citations (Scopus)

Abstract

Molecular cloning and transcriptional activation studies have revealed a new protein similar to the steroid hormone receptors and which responds specifically to vitamin A metabolites. This protein is substantially different in primary structure and ligand specificity from the products of the previously described retinoic acid receptor gene family. By indicating the existence of an additional pathway through which retinoic acid may exert its effects, these data lead to a re-evaluation of retinoid physiology.

Original languageEnglish (US)
Pages (from-to)224-229
Number of pages6
JournalNature
Volume345
Issue number6272
StatePublished - May 17 1990

Fingerprint

Cytoplasmic and Nuclear Receptors
Tretinoin
Retinoic Acid Receptors
Steroid Receptors
Retinoids
Molecular Cloning
Vitamin A
Transcriptional Activation
Proteins
Hormones
Ligands
Genes

ASJC Scopus subject areas

  • General

Cite this

Mangelsdorf, D. J., Ong, E. S., Dyck, J. A., & Evans, R. M. (1990). Nuclear receptor that identifies a novel retinoic acid response pathway. Nature, 345(6272), 224-229.

Nuclear receptor that identifies a novel retinoic acid response pathway. / Mangelsdorf, David J.; Ong, Estelita S.; Dyck, Jacqueline A.; Evans, Ronald M.

In: Nature, Vol. 345, No. 6272, 17.05.1990, p. 224-229.

Research output: Contribution to journalArticle

Mangelsdorf, DJ, Ong, ES, Dyck, JA & Evans, RM 1990, 'Nuclear receptor that identifies a novel retinoic acid response pathway', Nature, vol. 345, no. 6272, pp. 224-229.
Mangelsdorf DJ, Ong ES, Dyck JA, Evans RM. Nuclear receptor that identifies a novel retinoic acid response pathway. Nature. 1990 May 17;345(6272):224-229.
Mangelsdorf, David J. ; Ong, Estelita S. ; Dyck, Jacqueline A. ; Evans, Ronald M. / Nuclear receptor that identifies a novel retinoic acid response pathway. In: Nature. 1990 ; Vol. 345, No. 6272. pp. 224-229.
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