Nuclear receptor that identifies a novel retinoic acid response pathway

David J. Mangelsdorf, Estelita S. Ong, Jacqueline A. Dyck, Ronald M. Evans

Research output: Contribution to journalArticle

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Abstract

Molecular cloning and transcriptional activation studies have revealed a new protein similar to the steroid hormone receptors and which responds specifically to vitamin A metabolites. This protein is substantially different in primary structure and ligand specificity from the products of the previously described retinoic acid receptor gene family. By indicating the existence of an additional pathway through which retinoic acid may exert its effects, these data lead to a re-evaluation of retinoid physiology.

Original languageEnglish (US)
Pages (from-to)224-229
Number of pages6
JournalNature
Volume345
Issue number6272
DOIs
StatePublished - Jan 1 1990

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