Nuclear receptors and lipid physiology: Opening the x-files

A. Chawta, J. J. Repa, R. M. Evans, D. J. Mangelsdorf

Research output: Contribution to journalArticle

1526 Scopus citations

Abstract

Cholesterol, fatty acids, fat-soluble vitamins, and other lipids present in our diets are not only nutritionally important but serve as precursors for ligands that bind to receptors in the nucleus. To become biologically active, these lipids must first be absorbed by the intestine and transformed by metabolic enzymes before they are delivered to their sites of action in the body. Ultimately, the lipids must be eliminated to maintain a normal physiological state. The need to coordinate this entire lipid-based metabolic signaling cascade raises important questions regarding the mechanisms that govern these pathways. Specifically, what is the nature of communication between these bioactive lipids and their receptors, binding proteins, transporters, and metabolizing enzymes that links them physiologically and speaks to a higher lever of metabolic control? Some general principles that govern the actions of this class of bioactive lipids and their nuclear receptors are considered here, and the scheme that emerges reveals a complex molecular script at work.

Original languageEnglish (US)
Pages (from-to)1866-1870
Number of pages5
JournalScience
Volume294
Issue number5548
DOIs
Publication statusPublished - Nov 30 2001

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ASJC Scopus subject areas

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