Nuclear receptors I. Nuclear receptors and bile acid homeostasis

Bryan Goodwin, Steven A. Kliewer

Research output: Contribution to journalArticle

54 Scopus citations

Abstract

Bile acids are required for the absorption of lipids and fat-soluble vitamins. The hepatic biosynthesis of bile acids is a major pathway for the catabolism and removal of cholesterol from the body. Because of their intrinsic toxicity, bile acid synthesis, transport, and metabolism must be tightly regulated. It is now apparent that members of the nuclear receptor family of lipid-activated transcription factors are key regulators of these physiological processes. A greater understanding of these receptors should afford novel opportunities for therapeutic intervention in chronic diseases such as cholestasis and dyslipidemia.

Original languageEnglish (US)
Pages (from-to)G926-G931
JournalAmerican Journal of Physiology - Gastrointestinal and Liver Physiology
Volume282
Issue number6 45-6
StatePublished - Jun 27 2002

Keywords

  • Bile acids
  • Farnesoid X receptor
  • Pregnane X receptor

ASJC Scopus subject areas

  • Physiology
  • Hepatology
  • Gastroenterology
  • Physiology (medical)

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