TY - JOUR
T1 - Nuclear receptors, RXR, and the big bang
AU - Evans, Ronald M.
AU - Mangelsdorf, David J.
N1 - Funding Information:
We thank R. Yu, M. Downes, A. Atkins, S. Kliewer, and N. McKenna for discussions and critical input, J. Simon for artwork, and C. Brondos and E. Ong for administrative assistance. R.M.E. holds the March of Dimes Chair in Molecular and Developmental Biology at the Salk Institute and is supported by grants from the National Institutes of Health (NIH) (DK057978, HL105278, DK090962, HL088093, ES010337 and CA014195), as well as the Helmsley Charitable Trust, Samuel Waxman Cancer Research Foundation, and Ipsen/Biomeasure. D.J.M. is supported by the NIH (R01DK067158) and the Robert A. Welch Foundation (grant I-1275). R.M.E. and D.J.M. are investigators of the Howard Hughes Medical Institute.
PY - 2014/3/27
Y1 - 2014/3/27
N2 - Isolation of genes encoding the receptors for steroids, retinoids, vitamin D, and thyroid hormone and their structural and functional analysis revealed an evolutionarily conserved template for nuclear hormone receptors. This discovery sparked identification of numerous genes encoding related proteins, termed orphan receptors. Characterization of these orphan receptors and, in particular, of the retinoid X receptor (RXR) positioned nuclear receptors at the epicenter of the "Big Bang" of molecular endocrinology. This Review provides a personal perspective on nuclear receptors and explores their integrated and coordinated signaling networks that are essential for multicellular life, highlighting the RXR heterodimer and its associated ligands and transcriptional mechanism.
AB - Isolation of genes encoding the receptors for steroids, retinoids, vitamin D, and thyroid hormone and their structural and functional analysis revealed an evolutionarily conserved template for nuclear hormone receptors. This discovery sparked identification of numerous genes encoding related proteins, termed orphan receptors. Characterization of these orphan receptors and, in particular, of the retinoid X receptor (RXR) positioned nuclear receptors at the epicenter of the "Big Bang" of molecular endocrinology. This Review provides a personal perspective on nuclear receptors and explores their integrated and coordinated signaling networks that are essential for multicellular life, highlighting the RXR heterodimer and its associated ligands and transcriptional mechanism.
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U2 - 10.1016/j.cell.2014.03.012
DO - 10.1016/j.cell.2014.03.012
M3 - Review article
C2 - 24679540
AN - SCOPUS:84897147399
SN - 0092-8674
VL - 157
SP - 255
EP - 266
JO - Cell
JF - Cell
IS - 1
ER -