Nucleophilic substitution at the acetalic center of mandelate 1,3-dioxolan-4-ones using magnesio-copper reagents: Application to the synthesis of chiral secondary alcohols.

Bertrand Heckmann, Charles Mioskowski, Jurong Yu, J R Falck

Research output: Contribution to journalArticle

14 Scopus citations


Ethereal magnesio-copper reagents, in contrast to lithio-copper reagents, add stereoselectively to mandelic acid derived 1,3-dioxolan-4-ones to afford optically active secondary alcohols after removal of the chiral auxiliary.

Original languageEnglish (US)
Pages (from-to)5201-5204
Number of pages4
JournalTetrahedron Letters
Issue number36
StatePublished - Sep 1 1992


ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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