Nucleotide excision repair and the ubiquitin proteasome pathway-Do all roads lead to Rome?

Simon H. Reed, Thomas G. Gillette

Research output: Contribution to journalReview articlepeer-review

43 Scopus citations

Abstract

It is clear that components of the proteasome and the ubiquitin proteasome pathway play a direct mechanistic role in the regulation of a variety of DNA repair processes. Intriguingly, a wealth of evidence suggests that this is also the case during the regulation of gene transcription. Here we review our current understanding of how the ubiquitin proteasome pathway influences nucleotide excision repair, and discuss how studies that investigate the role of this pathway in the regulation of gene transcription might also contribute to our mechanistic understanding of its role in DNA repair.

Original languageEnglish (US)
Pages (from-to)149-156
Number of pages8
JournalDNA repair
Volume6
Issue number2
DOIs
StatePublished - Feb 4 2007

Keywords

  • Non-proteolytic
  • Nucleotide excision repair
  • Rad23
  • Rad4
  • Ubiquitin proteasome pathway
  • XPC

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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