Abstract
Nucleotide excision repair (NER) is a fundamental DNA repair process that is ubiquitously distributed from bacteria to humans. The process is essential for the enzyme-catalyzed removal of various types of base damage from the nuclear genome, typically those that result in significant distortion of the helical structure of DNA. This article discusses the overview and biology of NER.
Original language | English (US) |
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Title of host publication | Encyclopedia of Biological Chemistry |
Subtitle of host publication | Second Edition |
Publisher | Elsevier Inc. |
Pages | 337-340 |
Number of pages | 4 |
ISBN (Electronic) | 9780123786319 |
ISBN (Print) | 9780123786302 |
DOIs | |
State | Published - Feb 15 2013 |
Keywords
- Human disease
- Nucleotide excision repair
- Pyrimidine dimmers
- UV radiation
- Xeroderma pigmentosum
ASJC Scopus subject areas
- General Biochemistry, Genetics and Molecular Biology