Nucleotide sequence of 3-hydroxy-3-methyl-glutaryl coenzyme A reductase, a glycoprotein of endoplasmic reticulum

Daniel J. Chin, Gregorio Gil, David W. Russell, Laura Liscum, Kenneth L. Luskey, Sandip K. Basu, Hiroto Okayama, Paul Berg, Joseph L. Goldstein, Michael S. Brown

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The nucleotide sequence of a 4.8-kilobase mRNA for hamster 3-hydroxy-3-methylglutaryl coenzyme A reductase, the endoplasmic reticulum enzyme that controls cholesterol biosynthesis, shows that it is a protein of 887 amino acids (molecular weight 97,092) which contains three potential sites for asparagine-linked glycosylation. The reductase is a transmembrane glycoprotein, but in contrast to many other transmembrane glycoproteins, it lacks a cleavable or Hydrophobie NH2-terminal signal sequence.

Original languageEnglish (US)
Pages (from-to)613-617
Number of pages5
Issue number5960
Publication statusPublished - 1984


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