Nucleotide sequence of 3-hydroxy-3-methyl-glutaryl coenzyme A reductase, a glycoprotein of endoplasmic reticulum

Daniel J. Chin, Gregorio Gil, David W. Russell, Laura Liscum, Kenneth L. Luskey, Sandip K. Basu, Hiroto Okayama, Paul Berg, Joseph L. Goldstein, Michael S. Brown

Research output: Contribution to journalArticle

149 Scopus citations

Abstract

The nucleotide sequence of a 4.8-kilobase mRNA for hamster 3-hydroxy-3-methylglutaryl coenzyme A reductase, the endoplasmic reticulum enzyme that controls cholesterol biosynthesis, shows that it is a protein of 887 amino acids (molecular weight 97,092) which contains three potential sites for asparagine-linked glycosylation. The reductase is a transmembrane glycoprotein, but in contrast to many other transmembrane glycoproteins, it lacks a cleavable or Hydrophobie NH2-terminal signal sequence.

Original languageEnglish (US)
Pages (from-to)613-617
Number of pages5
JournalNature
Volume308
Issue number5960
DOIs
Publication statusPublished - 1984

    Fingerprint

ASJC Scopus subject areas

  • General

Cite this