Nutrient intake and cerebral metabolism in healthy middle-aged adults: Implications for cognitive aging

Stephanie Oleson, Mitzi M. Gonzales, Takashi Tarumi, Jaimie N. Davis, Carolyn K. Cassill, Hirofumi Tanaka, Andreana P. Haley

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Objectives: Growing evidence suggests dietary factors influence cognition, but the effects of nutrient intake on cerebral metabolism in adults are currently unknown. The present study investigated the relationship between major macronutrient intake (fat, carbohydrate, and protein) and cerebral neurochemical profiles in middle-aged adults. Methods: Thirty-six adults recorded dietary intake for 3 days prior to completing cognitive testing and a proton magnetic resonance spectroscopy (1H-MRS) scan. 1H-MRS of occipitoparietal gray matter was used to assess glutamate (Glu), N-acetyl-aspartate (NAA), choline (Cho), and myo-inositol (mI) relative to creatine (Cr) levels. Results: Regression analyses revealed that high intake of polyunsaturated fatty acids (PUFAs) was associated with lower cerebral Glu/Cr (P = 0.005), and high intake of saturated fat (SFA) was associated with poorer memory function (P = 0.030) independent of age, sex, education, estimated intelligence, total caloric intake, and body mass index. Discussion: In midlife, greater PUFA intake (ω-3 and ω-6) may be associated with lower cerebral glutamate, potentially indicating more efficient cellular reuptake of glutamate. SFA intake, on the other hand, was linked with poorer memory performance. These results suggest that dietary fat intake modification may be an important intervention target for the prevention of cognitive decline.

Original languageEnglish (US)
Pages (from-to)489-496
Number of pages8
JournalNutritional Neuroscience
Volume20
Issue number8
DOIs
StatePublished - Sep 14 2017

Fingerprint

Glutamic Acid
Food
Creatine
Fats
Unsaturated Fatty Acids
Sex Education
Dietary Fats
Inositol
Choline
Energy Intake
Intelligence
Cognition
Body Mass Index
Regression Analysis
Carbohydrates
Cognitive Aging
Proton Magnetic Resonance Spectroscopy
Proteins

Keywords

  • Aging
  • Diet
  • Executive function
  • Memory
  • Polyunsaturated fat
  • Proton magnetic resonance spectroscopy
  • Saturated fat

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Neuroscience(all)
  • Nutrition and Dietetics

Cite this

Oleson, S., Gonzales, M. M., Tarumi, T., Davis, J. N., Cassill, C. K., Tanaka, H., & Haley, A. P. (2017). Nutrient intake and cerebral metabolism in healthy middle-aged adults: Implications for cognitive aging. Nutritional Neuroscience, 20(8), 489-496. https://doi.org/10.1080/1028415X.2016.1186341

Nutrient intake and cerebral metabolism in healthy middle-aged adults : Implications for cognitive aging. / Oleson, Stephanie; Gonzales, Mitzi M.; Tarumi, Takashi; Davis, Jaimie N.; Cassill, Carolyn K.; Tanaka, Hirofumi; Haley, Andreana P.

In: Nutritional Neuroscience, Vol. 20, No. 8, 14.09.2017, p. 489-496.

Research output: Contribution to journalArticle

Oleson, S, Gonzales, MM, Tarumi, T, Davis, JN, Cassill, CK, Tanaka, H & Haley, AP 2017, 'Nutrient intake and cerebral metabolism in healthy middle-aged adults: Implications for cognitive aging', Nutritional Neuroscience, vol. 20, no. 8, pp. 489-496. https://doi.org/10.1080/1028415X.2016.1186341
Oleson, Stephanie ; Gonzales, Mitzi M. ; Tarumi, Takashi ; Davis, Jaimie N. ; Cassill, Carolyn K. ; Tanaka, Hirofumi ; Haley, Andreana P. / Nutrient intake and cerebral metabolism in healthy middle-aged adults : Implications for cognitive aging. In: Nutritional Neuroscience. 2017 ; Vol. 20, No. 8. pp. 489-496.
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