@article{8877c11c3ab54efc83a7085e1fcf0b2b,
title = "Nutrient sensing and utilization: Getting to the heart of metabolic flexibility",
abstract = "A central feature of obesity-related cardiometabolic diseases is the impaired ability to transition between fatty acid and glucose metabolism. This impairment, referred to as {"}metabolic inflexibility{"}, occurs in a number of tissues, including the heart. Although the heart normally prefers to metabolize fatty acids over glucose, the inability to upregulate glucose metabolism under energetically demanding conditions contributes to a pathological state involving energy imbalance, impaired contractility, and post-translational protein modifications. This review discusses pathophysiologic processes that contribute to cardiac metabolic inflexibility and speculates on the potential physiologic origins that lead to the current state of cardiometabolic disease in an obesogenic environment.",
keywords = "Cardiovascular, Metabolic inflexibility, Mitochondrial, Obesity, Peroxisome, ROS",
author = "Griffin, {Timothy M.} and Humphries, {Kenneth M.} and Michael Kinter and Lim, {Hui Ying} and Szweda, {Luke I.}",
note = "Funding Information: We would like to thank our colleagues, Drs. Holly Van Remmen, Scott Plafker, and Ann Louise Olson, as well as the members of our labs, for many insightful discussions on the topics discussed in this review. This work was supported by the National Institute of General Medical Sciences ( P20GM103441 to TMG; P20GM104934 to KMH; P20GM103636 to HYL), the National Institute of Arthritis and Musculoskeletal and Skin Diseases ( R03AR066828 to TMG), and the National Institute on Aging ( R01AG049058 to TMG) of the National Institutes of Health. Support also from the American Heart Association ( 14GRNT20510031 to KMH and 13SDG14680005 to HYL). The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health or the American Heart Association. Publisher Copyright: {\textcopyright} 2015 Elsevier B.V. All rights reserved.",
year = "2016",
month = may,
day = "1",
doi = "10.1016/j.biochi.2015.10.013",
language = "English (US)",
volume = "124",
pages = "74--83",
journal = "Biochimie",
issn = "0300-9084",
publisher = "Elsevier",
}