Nutrigenomics, the microbiome, and gene-environment interactions: New directions in cardiovascular disease research, prevention, and treatment

Jane F. Ferguson, Hooman Allayee, Robert E. Gerszten, Folami Ideraabdullah, Penny M. Kris-Etherton, José M. Ordovás, Eric B. Rimm, Thomas J. Wang, Brian J. Bennett

Research output: Contribution to journalArticle

41 Scopus citations

Abstract

Cardiometabolic diseases are the leading cause of death worldwide and are strongly linked to both genetic and nutritional factors. The field of nutrigenomics encompasses multiple approaches aimed at understanding the effects of diet on health or disease development, including nutrigenetic studies investigating the relationship between genetic variants and diet in modulating cardiometabolic risk, as well as the effects of dietary components on multiple "omic" measures, including transcriptomics, metabolomics, proteomics, lipidomics, epigenetic modifications, and the microbiome. Here, we describe the current state of the field of nutrigenomics with respect to cardiometabolic disease research and outline a direction for the integration of multiple omics techniques in future nutrigenomic studies aimed at understanding mechanisms and developing new therapeutic options for cardiometabolic disease treatment and prevention.

Original languageEnglish (US)
Pages (from-to)291-313
Number of pages23
JournalCirculation: Cardiovascular Genetics
Volume9
Issue number3
DOIs
StatePublished - Jun 1 2016
Externally publishedYes

Keywords

  • AHA Scientific Statements
  • diet
  • metagenomics
  • microbiota
  • nutrigenetics
  • nutrigenomics
  • nutritional status

ASJC Scopus subject areas

  • Genetics
  • Cardiology and Cardiovascular Medicine
  • Genetics(clinical)

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    Ferguson, J. F., Allayee, H., Gerszten, R. E., Ideraabdullah, F., Kris-Etherton, P. M., Ordovás, J. M., Rimm, E. B., Wang, T. J., & Bennett, B. J. (2016). Nutrigenomics, the microbiome, and gene-environment interactions: New directions in cardiovascular disease research, prevention, and treatment. Circulation: Cardiovascular Genetics, 9(3), 291-313. https://doi.org/10.1161/HCG.0000000000000030