Obesity and metabolic syndrome in circadian Clock mutant nice

Fred W. Turek, Corinne Joshu, Akira Kohsaka, Emily Lin, Ganka Ivanova, Erin McDearmon, Aaron Laposky, Sue Losee-Olson, Amy Easton, Dalan R. Jensen, Robert H. Eckel, Joseph S. Takahashi, Joseph Bass

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The CLOCK transcription factor is a key component of the molecular circadian clock within pacemaker neurons of the hypothalamic suprachiasmatic nucleus. We found that homozygous Clock mutant mice have a greatly attenuated diurnal feeding rhythm, are hyperphagic and obese, and develop a metabolic syndrome of hyperleptinemia, hyperlipidemia, hepatic steatosis, hyperglycemia, and hypoinsulinemia. Expression of transcripts encoding selected hypothalamic peptides associated with energy balance was attenuated in the Clock mutant mice. These results suggest that the circadian clock gene network plays an important role in mammalian energy balance.

Original languageEnglish (US)
Pages (from-to)1043-1045
Number of pages3
Issue number5724
StatePublished - May 13 2005


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Turek, F. W., Joshu, C., Kohsaka, A., Lin, E., Ivanova, G., McDearmon, E., Laposky, A., Losee-Olson, S., Easton, A., Jensen, D. R., Eckel, R. H., Takahashi, J. S., & Bass, J. (2005). Obesity and metabolic syndrome in circadian Clock mutant nice. Science, 308(5724), 1043-1045. https://doi.org/10.1126/science.1108750