Obesity, bariatric surgery and type 2 diabetes - A systematic review

Cynthia V. Ferchak, Luigi F. Meneghini

Research output: Contribution to journalArticle

80 Citations (Scopus)

Abstract

Obesity is endemic in the United States and is closely linked to the development of type 2 diabetes. Both obesity and diabetes are responsible for significant morbidity and mortality. Likewise, both conditions are resistant to treatment. Recent studies have evaluated prevention of type 2 diabetes through intensive lifestyle intervention, while others are examining the impact of bariatric surgery on type 2 diabetes. This article presents an overview of the impact of bariatric surgical and lifestyle interventions on the prevention and treatment of type 2 diabetes. Although studies using a variety of bariatric surgical techniques are included, the focus is on two interventions in particular: the Roux-en-Y gastric bypass and the laparoscopic silicone gastric banding procedure. Outcomes of these procedures are further contrasted with recent lifestyle intervention studies, in particular, the Diabetes Prevention Program study. Gastric bypass studies have been associated with a 99 to 100% prevention of diabetes in patients with IGT and an 80 to 90% clinical resolution of diagnosed early type 2 diabetes. Gastric banding procedures are associated with a lower median (50-60%) clinical remission of type 2 diabetes. Lifestyle intervention studies of obese and glucose-intolerant patients have achieved a 50% reduction in the progression of IGT to diabetes over the short term, with no reported resolution of the disease. Weight loss by any means in the obese patient appears to prevent progression to type 2 diabetes, at least in the short term. Furthermore, sustained weight loss through bariatric surgical intervention is associated both with prevention of progression of IGT and with clinical remission of early type 2 diabetes.

Original languageEnglish (US)
Pages (from-to)438-445
Number of pages8
JournalDiabetes/Metabolism Research and Reviews
Volume20
Issue number6
DOIs
StatePublished - Nov 2004

Fingerprint

Bariatric Surgery
Medical problems
Surgery
Type 2 Diabetes Mellitus
Obesity
Bariatrics
Life Style
Gastric Bypass
Insulated gate bipolar transistors (IGBT)
Weight Loss
Stomach
Silicones
Morbidity
Glucose
Mortality
Therapeutics

Keywords

  • Bariatric surgery
  • Diabetes prevention
  • Obesity
  • Type 2 diabetes
  • Weight loss

ASJC Scopus subject areas

  • Endocrinology
  • Biochemistry
  • Endocrinology, Diabetes and Metabolism

Cite this

Obesity, bariatric surgery and type 2 diabetes - A systematic review. / Ferchak, Cynthia V.; Meneghini, Luigi F.

In: Diabetes/Metabolism Research and Reviews, Vol. 20, No. 6, 11.2004, p. 438-445.

Research output: Contribution to journalArticle

@article{f1959cbe88684c8791218012729ab295,
title = "Obesity, bariatric surgery and type 2 diabetes - A systematic review",
abstract = "Obesity is endemic in the United States and is closely linked to the development of type 2 diabetes. Both obesity and diabetes are responsible for significant morbidity and mortality. Likewise, both conditions are resistant to treatment. Recent studies have evaluated prevention of type 2 diabetes through intensive lifestyle intervention, while others are examining the impact of bariatric surgery on type 2 diabetes. This article presents an overview of the impact of bariatric surgical and lifestyle interventions on the prevention and treatment of type 2 diabetes. Although studies using a variety of bariatric surgical techniques are included, the focus is on two interventions in particular: the Roux-en-Y gastric bypass and the laparoscopic silicone gastric banding procedure. Outcomes of these procedures are further contrasted with recent lifestyle intervention studies, in particular, the Diabetes Prevention Program study. Gastric bypass studies have been associated with a 99 to 100{\%} prevention of diabetes in patients with IGT and an 80 to 90{\%} clinical resolution of diagnosed early type 2 diabetes. Gastric banding procedures are associated with a lower median (50-60{\%}) clinical remission of type 2 diabetes. Lifestyle intervention studies of obese and glucose-intolerant patients have achieved a 50{\%} reduction in the progression of IGT to diabetes over the short term, with no reported resolution of the disease. Weight loss by any means in the obese patient appears to prevent progression to type 2 diabetes, at least in the short term. Furthermore, sustained weight loss through bariatric surgical intervention is associated both with prevention of progression of IGT and with clinical remission of early type 2 diabetes.",
keywords = "Bariatric surgery, Diabetes prevention, Obesity, Type 2 diabetes, Weight loss",
author = "Ferchak, {Cynthia V.} and Meneghini, {Luigi F.}",
year = "2004",
month = "11",
doi = "10.1002/dmrr.507",
language = "English (US)",
volume = "20",
pages = "438--445",
journal = "Diabetes/Metabolism Research and Reviews",
issn = "1520-7552",
publisher = "John Wiley and Sons Ltd",
number = "6",

}

TY - JOUR

T1 - Obesity, bariatric surgery and type 2 diabetes - A systematic review

AU - Ferchak, Cynthia V.

AU - Meneghini, Luigi F.

PY - 2004/11

Y1 - 2004/11

N2 - Obesity is endemic in the United States and is closely linked to the development of type 2 diabetes. Both obesity and diabetes are responsible for significant morbidity and mortality. Likewise, both conditions are resistant to treatment. Recent studies have evaluated prevention of type 2 diabetes through intensive lifestyle intervention, while others are examining the impact of bariatric surgery on type 2 diabetes. This article presents an overview of the impact of bariatric surgical and lifestyle interventions on the prevention and treatment of type 2 diabetes. Although studies using a variety of bariatric surgical techniques are included, the focus is on two interventions in particular: the Roux-en-Y gastric bypass and the laparoscopic silicone gastric banding procedure. Outcomes of these procedures are further contrasted with recent lifestyle intervention studies, in particular, the Diabetes Prevention Program study. Gastric bypass studies have been associated with a 99 to 100% prevention of diabetes in patients with IGT and an 80 to 90% clinical resolution of diagnosed early type 2 diabetes. Gastric banding procedures are associated with a lower median (50-60%) clinical remission of type 2 diabetes. Lifestyle intervention studies of obese and glucose-intolerant patients have achieved a 50% reduction in the progression of IGT to diabetes over the short term, with no reported resolution of the disease. Weight loss by any means in the obese patient appears to prevent progression to type 2 diabetes, at least in the short term. Furthermore, sustained weight loss through bariatric surgical intervention is associated both with prevention of progression of IGT and with clinical remission of early type 2 diabetes.

AB - Obesity is endemic in the United States and is closely linked to the development of type 2 diabetes. Both obesity and diabetes are responsible for significant morbidity and mortality. Likewise, both conditions are resistant to treatment. Recent studies have evaluated prevention of type 2 diabetes through intensive lifestyle intervention, while others are examining the impact of bariatric surgery on type 2 diabetes. This article presents an overview of the impact of bariatric surgical and lifestyle interventions on the prevention and treatment of type 2 diabetes. Although studies using a variety of bariatric surgical techniques are included, the focus is on two interventions in particular: the Roux-en-Y gastric bypass and the laparoscopic silicone gastric banding procedure. Outcomes of these procedures are further contrasted with recent lifestyle intervention studies, in particular, the Diabetes Prevention Program study. Gastric bypass studies have been associated with a 99 to 100% prevention of diabetes in patients with IGT and an 80 to 90% clinical resolution of diagnosed early type 2 diabetes. Gastric banding procedures are associated with a lower median (50-60%) clinical remission of type 2 diabetes. Lifestyle intervention studies of obese and glucose-intolerant patients have achieved a 50% reduction in the progression of IGT to diabetes over the short term, with no reported resolution of the disease. Weight loss by any means in the obese patient appears to prevent progression to type 2 diabetes, at least in the short term. Furthermore, sustained weight loss through bariatric surgical intervention is associated both with prevention of progression of IGT and with clinical remission of early type 2 diabetes.

KW - Bariatric surgery

KW - Diabetes prevention

KW - Obesity

KW - Type 2 diabetes

KW - Weight loss

UR - http://www.scopus.com/inward/record.url?scp=11144261930&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=11144261930&partnerID=8YFLogxK

U2 - 10.1002/dmrr.507

DO - 10.1002/dmrr.507

M3 - Article

C2 - 15386803

AN - SCOPUS:11144261930

VL - 20

SP - 438

EP - 445

JO - Diabetes/Metabolism Research and Reviews

JF - Diabetes/Metabolism Research and Reviews

SN - 1520-7552

IS - 6

ER -