TY - JOUR
T1 - Obesity
T2 - Challenges to ventilatory control during exercise-A brief review
AU - Babb, Tony G.
N1 - Funding Information:
The author wishes to thank Joseph Genovese for his assistance in preparing the figures and Drs. Vipa Bernhardt and Matthew Spencer for their editorial comments on the review. This publication was supported in part by NIH HL-096782 , King Charitable Foundation Trust, Susan Lay Atwell Gift for Pulmonary Research, Cain Foundation, and Texas Health Presbyterian Hospital Dallas .
PY - 2013/11/1
Y1 - 2013/11/1
N2 - Among the many physiological changes induced by obesity, it also presents a unique challenge to ventilatory control during exercise due to increased metabolic demand of moving larger limbs, increased work of breathing due to extra weight on the chest wall, and changes in breathing mechanics. These challenges to ventilatory control in obesity can be inconspicuous or overt among obese adults but for the most part adaptation of ventilatory control during exercise in obesity appears remarkably unnoticed in the majority of obese people. In this brief review, the changes to ventilatory control required for maintaining normal ventilation during exercise will be examined, especially the interaction between respiratory neural drive and ventilation. Also, gaps in our current knowledge will be discussed.
AB - Among the many physiological changes induced by obesity, it also presents a unique challenge to ventilatory control during exercise due to increased metabolic demand of moving larger limbs, increased work of breathing due to extra weight on the chest wall, and changes in breathing mechanics. These challenges to ventilatory control in obesity can be inconspicuous or overt among obese adults but for the most part adaptation of ventilatory control during exercise in obesity appears remarkably unnoticed in the majority of obese people. In this brief review, the changes to ventilatory control required for maintaining normal ventilation during exercise will be examined, especially the interaction between respiratory neural drive and ventilation. Also, gaps in our current knowledge will be discussed.
KW - Exercise hyperpnea
KW - Gas exchange
KW - Respiratory neural drive
KW - Respiratory neural output
KW - Ventilation
KW - Ventilatory response to exercise
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U2 - 10.1016/j.resp.2013.05.019
DO - 10.1016/j.resp.2013.05.019
M3 - Review article
C2 - 23707540
AN - SCOPUS:84886243079
SN - 1569-9048
VL - 189
SP - 364
EP - 370
JO - Respiratory Physiology and Neurobiology
JF - Respiratory Physiology and Neurobiology
IS - 2
ER -