TY - JOUR
T1 - Obesity is associated with better survival and functional outcome after acute intracerebral hemorrhage
AU - Sun, Weiping
AU - Xian, Ying
AU - Huang, Yining
AU - Sun, Wei
AU - Liu, Ran
AU - Li, Fan
AU - Wei, Jade W.
AU - Wang, Ji Guang
AU - Liu, Ming
AU - Wu, Yangfeng
AU - Wong, Lawrence K.S.
AU - Anderson, Craig S.
N1 - Publisher Copyright:
© 2016
PY - 2016/11/15
Y1 - 2016/11/15
N2 - Objective To evaluate the association of obesity measured by body mass index (BMI) with mortality and functional outcome in patients with acute intracerebral hemorrhage (ICH). Methods Data were from 1571 patients with ICH enrolled in a national, multi-centre, prospective, hospital-based register: the ChinaQUEST (Quality Evaluation of Stroke Care and Treatment) study. The outcomes included all-cause mortality at 12 months, and death or high dependency at 3 and 12 months. High dependency was defined as a modified Rankin Scale score of 3–5. Results Of 1571 patients with ICH, 109 were underweight (BMI < 18.5 kg/m2), 657 were normal-weight (BMI 18.5–23 kg/m2), 341 were overweight (BMI 23–25 kg/m2) and 464 were obese (BMI ≥ 25 kg/m2). Compared with normal-weight patients, obese patients had significantly decreased risks of death at 12 months (HR: 0.71, 95% CI: 0.56–0.91) and death or high dependency at 3 and 12 months (OR: 0.71, 95% CI: 0.53–0.95; OR: 0.69, 95% CI: 0.51–0.94) after adjusting for baseline characteristics. Neither underweight nor overweight was associated with these three outcomes significantly. Conclusions In patients with acute ICH, being obese is associated with a decreased mortality and better functional recovery. Further interventional studies are needed to guide the weight management strategy for patients with ICH.
AB - Objective To evaluate the association of obesity measured by body mass index (BMI) with mortality and functional outcome in patients with acute intracerebral hemorrhage (ICH). Methods Data were from 1571 patients with ICH enrolled in a national, multi-centre, prospective, hospital-based register: the ChinaQUEST (Quality Evaluation of Stroke Care and Treatment) study. The outcomes included all-cause mortality at 12 months, and death or high dependency at 3 and 12 months. High dependency was defined as a modified Rankin Scale score of 3–5. Results Of 1571 patients with ICH, 109 were underweight (BMI < 18.5 kg/m2), 657 were normal-weight (BMI 18.5–23 kg/m2), 341 were overweight (BMI 23–25 kg/m2) and 464 were obese (BMI ≥ 25 kg/m2). Compared with normal-weight patients, obese patients had significantly decreased risks of death at 12 months (HR: 0.71, 95% CI: 0.56–0.91) and death or high dependency at 3 and 12 months (OR: 0.71, 95% CI: 0.53–0.95; OR: 0.69, 95% CI: 0.51–0.94) after adjusting for baseline characteristics. Neither underweight nor overweight was associated with these three outcomes significantly. Conclusions In patients with acute ICH, being obese is associated with a decreased mortality and better functional recovery. Further interventional studies are needed to guide the weight management strategy for patients with ICH.
KW - Dependency
KW - Intracerebral hemorrhage
KW - Mortality
KW - Obesity
KW - Outcome
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U2 - 10.1016/j.jns.2016.09.029
DO - 10.1016/j.jns.2016.09.029
M3 - Article
C2 - 27772744
AN - SCOPUS:84988664020
SN - 0022-510X
VL - 370
SP - 140
EP - 144
JO - Journal of the Neurological Sciences
JF - Journal of the Neurological Sciences
ER -