Observation-only management of early stage, medically inoperable lung cancer: Poor outcome

Ronald C. McGarry, Guobin Song, Paul Des Rosiers, Robert Timmerman

Research output: Contribution to journalArticle

156 Citations (Scopus)

Abstract

Study objectives: To assess the treatments received and outcomes of patients with early stage non-small cell lung carcinoma (NSCLC). Design: A retrospective study of patients identified from the institutional tumor registry between 1994 and 1999. Setting: The Richard L. Roudebush VA Medical Center, Indianapolis, IN. Patients: All patients with stage I and II NSCLC as identified above. Interventions: None. Measurements and results: Of 128 patients identified, 49 patients received no cancer treatment, 36 patients received radiation therapy only, and 43 patients were treated with primary surgery. Median ± SD survival time following surgery was 46.2 ± 3.15 months; for no treatment, 14.2 ± 2.37 months (p = 3.2 × 10-6); and radiotherapy alone, 19.9 ± 5.6 months (p = 0.0005). Of those who received no specific cancer treatment, 14 patients refused treatment and the remainder were not treated for a variety of medical reasons. Cause of death was cancer in 53% of untreated patients and 43% for those receiving radiotherapy. Radiotherapy was administered for postobstructive atelectasis, hemoptysis, increasing tumor size, pain, pleural effusion, and medical inoperability. Radiation dosages had no apparent standard. No significant differences in survival were found for patients receiving radiotherapy with either curative or palliative intent (20.3 months vs 16.0 months, respectively; p = 0.229). Conclusions: Within the limitations of this retrospective study, it appears that untreated early stage lung cancer has a poor outcome, with > 50% of patients dying of lung cancer. Surgery remains the treatment of choice, but lung cancer screening programs will result in increasing numbers of medically inoperable patients with no clear policies for their management.

Original languageEnglish (US)
Pages (from-to)1155-1158
Number of pages4
JournalChest
Volume121
Issue number4
DOIs
StatePublished - 2002

Fingerprint

Lung Neoplasms
Observation
Radiotherapy
Neoplasms
Non-Small Cell Lung Carcinoma
Retrospective Studies
Therapeutics
Radiation Dosage
Pulmonary Atelectasis
Survival
Hemoptysis
Pleural Effusion
Early Detection of Cancer
Registries
Cause of Death
Pain

Keywords

  • Medically inoperable
  • Non-small cell lung cancer
  • Observation
  • Radiotherapy
  • Surgery

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Cite this

Observation-only management of early stage, medically inoperable lung cancer : Poor outcome. / McGarry, Ronald C.; Song, Guobin; Des Rosiers, Paul; Timmerman, Robert.

In: Chest, Vol. 121, No. 4, 2002, p. 1155-1158.

Research output: Contribution to journalArticle

McGarry, Ronald C. ; Song, Guobin ; Des Rosiers, Paul ; Timmerman, Robert. / Observation-only management of early stage, medically inoperable lung cancer : Poor outcome. In: Chest. 2002 ; Vol. 121, No. 4. pp. 1155-1158.
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abstract = "Study objectives: To assess the treatments received and outcomes of patients with early stage non-small cell lung carcinoma (NSCLC). Design: A retrospective study of patients identified from the institutional tumor registry between 1994 and 1999. Setting: The Richard L. Roudebush VA Medical Center, Indianapolis, IN. Patients: All patients with stage I and II NSCLC as identified above. Interventions: None. Measurements and results: Of 128 patients identified, 49 patients received no cancer treatment, 36 patients received radiation therapy only, and 43 patients were treated with primary surgery. Median ± SD survival time following surgery was 46.2 ± 3.15 months; for no treatment, 14.2 ± 2.37 months (p = 3.2 × 10-6); and radiotherapy alone, 19.9 ± 5.6 months (p = 0.0005). Of those who received no specific cancer treatment, 14 patients refused treatment and the remainder were not treated for a variety of medical reasons. Cause of death was cancer in 53{\%} of untreated patients and 43{\%} for those receiving radiotherapy. Radiotherapy was administered for postobstructive atelectasis, hemoptysis, increasing tumor size, pain, pleural effusion, and medical inoperability. Radiation dosages had no apparent standard. No significant differences in survival were found for patients receiving radiotherapy with either curative or palliative intent (20.3 months vs 16.0 months, respectively; p = 0.229). Conclusions: Within the limitations of this retrospective study, it appears that untreated early stage lung cancer has a poor outcome, with > 50{\%} of patients dying of lung cancer. Surgery remains the treatment of choice, but lung cancer screening programs will result in increasing numbers of medically inoperable patients with no clear policies for their management.",
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AB - Study objectives: To assess the treatments received and outcomes of patients with early stage non-small cell lung carcinoma (NSCLC). Design: A retrospective study of patients identified from the institutional tumor registry between 1994 and 1999. Setting: The Richard L. Roudebush VA Medical Center, Indianapolis, IN. Patients: All patients with stage I and II NSCLC as identified above. Interventions: None. Measurements and results: Of 128 patients identified, 49 patients received no cancer treatment, 36 patients received radiation therapy only, and 43 patients were treated with primary surgery. Median ± SD survival time following surgery was 46.2 ± 3.15 months; for no treatment, 14.2 ± 2.37 months (p = 3.2 × 10-6); and radiotherapy alone, 19.9 ± 5.6 months (p = 0.0005). Of those who received no specific cancer treatment, 14 patients refused treatment and the remainder were not treated for a variety of medical reasons. Cause of death was cancer in 53% of untreated patients and 43% for those receiving radiotherapy. Radiotherapy was administered for postobstructive atelectasis, hemoptysis, increasing tumor size, pain, pleural effusion, and medical inoperability. Radiation dosages had no apparent standard. No significant differences in survival were found for patients receiving radiotherapy with either curative or palliative intent (20.3 months vs 16.0 months, respectively; p = 0.229). Conclusions: Within the limitations of this retrospective study, it appears that untreated early stage lung cancer has a poor outcome, with > 50% of patients dying of lung cancer. Surgery remains the treatment of choice, but lung cancer screening programs will result in increasing numbers of medically inoperable patients with no clear policies for their management.

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