Observations on the pathological spectrum and clinical course of microsporidiosis in men infected with the human immunodeficiency virus: Follow-up study

L. Rabeneck, R. M. Genta, F. Gyorkey, J. E. Clarridge, P. Gyorkey, L. W. Foote

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

The purposes of this research were to determine whether microsporidian infection is accompanied by structural alterations of the duodenal mucosa and to characterize the clinical an d morphological evolution of intestinal microsporidiosis. In a previous systematic electron microscopic evaluation of mucosal biopsy specimens from patients with human immunodeficiency virus infection, we detected Enterocytozoon bieneusi in the duodenal tissue of 31 men. This report concerns a follow-up study of these 31 men, who underwent repeated clinical and laboratory evaluations, including repeated duodenal biopsies. Eighteen men had chronic diarrhea at enrollment and 13 had no diarrhea. The CD4+ cell counts (per mm3) ranged from 10 to 660 and were normal for three men. E. bieneusi infection was accompanied by a wide spectrum of histopathology of duodenal tissue; over a mean follow-up of 15 months, no consistent change in duodenal mucosal morphology was observed, and diarrhea did not invariably develop. These observations indicate that diarrhea and severe villus injury do not invariably accompany infection. Further studies are needed to determine the relationship between E. bieneusi infection and clinical illness.

Original languageEnglish (US)
Pages (from-to)1229-1235
Number of pages7
JournalClinical Infectious Diseases
Volume20
Issue number5
StatePublished - 1995

Fingerprint

Microsporidiosis
Enterocytozoon
Diarrhea
HIV
Infection
Biopsy
Virus Diseases
CD4 Lymphocyte Count
Mucous Membrane
Electrons
Wounds and Injuries
Research

ASJC Scopus subject areas

  • Immunology

Cite this

Observations on the pathological spectrum and clinical course of microsporidiosis in men infected with the human immunodeficiency virus : Follow-up study. / Rabeneck, L.; Genta, R. M.; Gyorkey, F.; Clarridge, J. E.; Gyorkey, P.; Foote, L. W.

In: Clinical Infectious Diseases, Vol. 20, No. 5, 1995, p. 1229-1235.

Research output: Contribution to journalArticle

Rabeneck, L. ; Genta, R. M. ; Gyorkey, F. ; Clarridge, J. E. ; Gyorkey, P. ; Foote, L. W. / Observations on the pathological spectrum and clinical course of microsporidiosis in men infected with the human immunodeficiency virus : Follow-up study. In: Clinical Infectious Diseases. 1995 ; Vol. 20, No. 5. pp. 1229-1235.
@article{c89e273a24b941e6b6adccde37327175,
title = "Observations on the pathological spectrum and clinical course of microsporidiosis in men infected with the human immunodeficiency virus: Follow-up study",
abstract = "The purposes of this research were to determine whether microsporidian infection is accompanied by structural alterations of the duodenal mucosa and to characterize the clinical an d morphological evolution of intestinal microsporidiosis. In a previous systematic electron microscopic evaluation of mucosal biopsy specimens from patients with human immunodeficiency virus infection, we detected Enterocytozoon bieneusi in the duodenal tissue of 31 men. This report concerns a follow-up study of these 31 men, who underwent repeated clinical and laboratory evaluations, including repeated duodenal biopsies. Eighteen men had chronic diarrhea at enrollment and 13 had no diarrhea. The CD4+ cell counts (per mm3) ranged from 10 to 660 and were normal for three men. E. bieneusi infection was accompanied by a wide spectrum of histopathology of duodenal tissue; over a mean follow-up of 15 months, no consistent change in duodenal mucosal morphology was observed, and diarrhea did not invariably develop. These observations indicate that diarrhea and severe villus injury do not invariably accompany infection. Further studies are needed to determine the relationship between E. bieneusi infection and clinical illness.",
author = "L. Rabeneck and Genta, {R. M.} and F. Gyorkey and Clarridge, {J. E.} and P. Gyorkey and Foote, {L. W.}",
year = "1995",
language = "English (US)",
volume = "20",
pages = "1229--1235",
journal = "Clinical Infectious Diseases",
issn = "1058-4838",
publisher = "Oxford University Press",
number = "5",

}

TY - JOUR

T1 - Observations on the pathological spectrum and clinical course of microsporidiosis in men infected with the human immunodeficiency virus

T2 - Follow-up study

AU - Rabeneck, L.

AU - Genta, R. M.

AU - Gyorkey, F.

AU - Clarridge, J. E.

AU - Gyorkey, P.

AU - Foote, L. W.

PY - 1995

Y1 - 1995

N2 - The purposes of this research were to determine whether microsporidian infection is accompanied by structural alterations of the duodenal mucosa and to characterize the clinical an d morphological evolution of intestinal microsporidiosis. In a previous systematic electron microscopic evaluation of mucosal biopsy specimens from patients with human immunodeficiency virus infection, we detected Enterocytozoon bieneusi in the duodenal tissue of 31 men. This report concerns a follow-up study of these 31 men, who underwent repeated clinical and laboratory evaluations, including repeated duodenal biopsies. Eighteen men had chronic diarrhea at enrollment and 13 had no diarrhea. The CD4+ cell counts (per mm3) ranged from 10 to 660 and were normal for three men. E. bieneusi infection was accompanied by a wide spectrum of histopathology of duodenal tissue; over a mean follow-up of 15 months, no consistent change in duodenal mucosal morphology was observed, and diarrhea did not invariably develop. These observations indicate that diarrhea and severe villus injury do not invariably accompany infection. Further studies are needed to determine the relationship between E. bieneusi infection and clinical illness.

AB - The purposes of this research were to determine whether microsporidian infection is accompanied by structural alterations of the duodenal mucosa and to characterize the clinical an d morphological evolution of intestinal microsporidiosis. In a previous systematic electron microscopic evaluation of mucosal biopsy specimens from patients with human immunodeficiency virus infection, we detected Enterocytozoon bieneusi in the duodenal tissue of 31 men. This report concerns a follow-up study of these 31 men, who underwent repeated clinical and laboratory evaluations, including repeated duodenal biopsies. Eighteen men had chronic diarrhea at enrollment and 13 had no diarrhea. The CD4+ cell counts (per mm3) ranged from 10 to 660 and were normal for three men. E. bieneusi infection was accompanied by a wide spectrum of histopathology of duodenal tissue; over a mean follow-up of 15 months, no consistent change in duodenal mucosal morphology was observed, and diarrhea did not invariably develop. These observations indicate that diarrhea and severe villus injury do not invariably accompany infection. Further studies are needed to determine the relationship between E. bieneusi infection and clinical illness.

UR - http://www.scopus.com/inward/record.url?scp=0029058082&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0029058082&partnerID=8YFLogxK

M3 - Article

C2 - 7620003

AN - SCOPUS:0029058082

VL - 20

SP - 1229

EP - 1235

JO - Clinical Infectious Diseases

JF - Clinical Infectious Diseases

SN - 1058-4838

IS - 5

ER -