Occult hemorrhage in children with severe ITP

Adolfo Flores, George R. Buchanan

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

Little is known about the frequency and significance of clinically unapparent or occult hemorrhage in ITP. Therefore, we prospectively explored the sites and frequency of occult bleeding in children with severe ITP at diagnosis or upon symptomatic relapse in a prospective, single-institution cohort study of patients≤18 years of age and a platelet count≤10,000/mm3. Data collected included bleeding severity assessment, urinalysis, fecal occult blood testing, and non-contrast brain MRI. Stool and urine samples were tested within 7 days of diagnosis or symptomatic relapse. Three months after diagnosis or relapse a noncontrast brain MRI evaluated hemosiderin deposits resulting from prior localized hemorrhage. Fifty-two ITP patients were enrolled with a mean platelet count of 4,000/mm3. A significant occurrence of occult hemorrhage was identified in the urine (27%) compared with clinically overt hematuria (0.91%, P

Original languageEnglish (US)
Pages (from-to)287-290
Number of pages4
JournalAmerican Journal of Hematology
Volume91
Issue number3
DOIs
StatePublished - Mar 1 2016

ASJC Scopus subject areas

  • Hematology

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