Occult hepatitis B infection and its possible impact on chronic hepatitis C virus infection

Peiman Habibollahi, Saeid Safari, Nasser E. Daryani, Seyed M. Alavian

Research output: Contribution to journalReview article

18 Citations (Scopus)

Abstract

As a well-recognized clinical phenomenon, persistent detectable viral genome in liver or sera in the absence of other serological markers for active hepatitis B virus (HBV) replication is called occult HBV infection. The main mechanism through which occult infection occurs is not completely understood and several possible explanations, such as integration into human genome and maintenance in peripheral mononuclear cells, exist. Occult HBV infection has been reported in different populations, especially among patients with Hepatitis C (HCV) related liver disease. The probable impact of occult HBV in patients with chronic HCV infection has been previously investigated and the evidence suggests a possible correlation with lower response to anti-viral treatment, higher grades of liver histological changes, and also developing hepatocellular carcinoma. However, in the absence of conclusive results, further studies should be conducted to absolutely assess the impact of occult HBV contamination on the HCV related liver disease.

Original languageEnglish (US)
Pages (from-to)220-224
Number of pages5
JournalSaudi Journal of Gastroenterology
Volume15
Issue number4
DOIs
StatePublished - Oct 1 2009
Externally publishedYes

Fingerprint

Chronic Hepatitis C
Virus Diseases
Hepatitis B
Hepatitis B virus
Hepacivirus
Infection
Liver Diseases
Viral Genome
Liver
Human Genome
Hepatitis C
Virus Replication
Hepatocellular Carcinoma
Maintenance
Serum
Population

Keywords

  • Hepatitis B
  • Hepatitis C
  • Occult

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Occult hepatitis B infection and its possible impact on chronic hepatitis C virus infection. / Habibollahi, Peiman; Safari, Saeid; Daryani, Nasser E.; Alavian, Seyed M.

In: Saudi Journal of Gastroenterology, Vol. 15, No. 4, 01.10.2009, p. 220-224.

Research output: Contribution to journalReview article

Habibollahi, Peiman ; Safari, Saeid ; Daryani, Nasser E. ; Alavian, Seyed M. / Occult hepatitis B infection and its possible impact on chronic hepatitis C virus infection. In: Saudi Journal of Gastroenterology. 2009 ; Vol. 15, No. 4. pp. 220-224.
@article{be79e7708e104545af114e0788e10eeb,
title = "Occult hepatitis B infection and its possible impact on chronic hepatitis C virus infection",
abstract = "As a well-recognized clinical phenomenon, persistent detectable viral genome in liver or sera in the absence of other serological markers for active hepatitis B virus (HBV) replication is called occult HBV infection. The main mechanism through which occult infection occurs is not completely understood and several possible explanations, such as integration into human genome and maintenance in peripheral mononuclear cells, exist. Occult HBV infection has been reported in different populations, especially among patients with Hepatitis C (HCV) related liver disease. The probable impact of occult HBV in patients with chronic HCV infection has been previously investigated and the evidence suggests a possible correlation with lower response to anti-viral treatment, higher grades of liver histological changes, and also developing hepatocellular carcinoma. However, in the absence of conclusive results, further studies should be conducted to absolutely assess the impact of occult HBV contamination on the HCV related liver disease.",
keywords = "Hepatitis B, Hepatitis C, Occult",
author = "Peiman Habibollahi and Saeid Safari and Daryani, {Nasser E.} and Alavian, {Seyed M.}",
year = "2009",
month = "10",
day = "1",
doi = "10.4103/1319-3767.56089",
language = "English (US)",
volume = "15",
pages = "220--224",
journal = "Saudi Journal of Gastroenterology",
issn = "1319-3767",
publisher = "Medknow Publications and Media Pvt. Ltd",
number = "4",

}

TY - JOUR

T1 - Occult hepatitis B infection and its possible impact on chronic hepatitis C virus infection

AU - Habibollahi, Peiman

AU - Safari, Saeid

AU - Daryani, Nasser E.

AU - Alavian, Seyed M.

PY - 2009/10/1

Y1 - 2009/10/1

N2 - As a well-recognized clinical phenomenon, persistent detectable viral genome in liver or sera in the absence of other serological markers for active hepatitis B virus (HBV) replication is called occult HBV infection. The main mechanism through which occult infection occurs is not completely understood and several possible explanations, such as integration into human genome and maintenance in peripheral mononuclear cells, exist. Occult HBV infection has been reported in different populations, especially among patients with Hepatitis C (HCV) related liver disease. The probable impact of occult HBV in patients with chronic HCV infection has been previously investigated and the evidence suggests a possible correlation with lower response to anti-viral treatment, higher grades of liver histological changes, and also developing hepatocellular carcinoma. However, in the absence of conclusive results, further studies should be conducted to absolutely assess the impact of occult HBV contamination on the HCV related liver disease.

AB - As a well-recognized clinical phenomenon, persistent detectable viral genome in liver or sera in the absence of other serological markers for active hepatitis B virus (HBV) replication is called occult HBV infection. The main mechanism through which occult infection occurs is not completely understood and several possible explanations, such as integration into human genome and maintenance in peripheral mononuclear cells, exist. Occult HBV infection has been reported in different populations, especially among patients with Hepatitis C (HCV) related liver disease. The probable impact of occult HBV in patients with chronic HCV infection has been previously investigated and the evidence suggests a possible correlation with lower response to anti-viral treatment, higher grades of liver histological changes, and also developing hepatocellular carcinoma. However, in the absence of conclusive results, further studies should be conducted to absolutely assess the impact of occult HBV contamination on the HCV related liver disease.

KW - Hepatitis B

KW - Hepatitis C

KW - Occult

UR - http://www.scopus.com/inward/record.url?scp=70349843536&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=70349843536&partnerID=8YFLogxK

U2 - 10.4103/1319-3767.56089

DO - 10.4103/1319-3767.56089

M3 - Review article

C2 - 19794265

AN - SCOPUS:70349843536

VL - 15

SP - 220

EP - 224

JO - Saudi Journal of Gastroenterology

JF - Saudi Journal of Gastroenterology

SN - 1319-3767

IS - 4

ER -