Occurrence of glioma in pregnant patients: An institutional case series and review of the literature

Pawan Singh, Emmanuel Mantilla, Josie Sewell, Kimmo J Hatanpaa, Edward Pan

Research output: Contribution to journalArticle

Abstract

Background/Aim: Gliomas present a uniquely challenging clinical situation in the context of pregnancy, with no standard recommendations. This case series aimed to describe the treatment regimen and outcomes of five pregnant patients with gliomas. Patients and Methods: This is a retrospective study. A patient database from electronic medical records was evaluated to identify pregnant patients with gliomas treated at our institution between 2008-2018. Results: Five study patients who were pregnant with gliomas were identified. Of these, 4 were diagnosed during pregnancy, while 1 was diagnosed prior to her pregnancy. One patient had grade 2 astrocytoma, 1 had grade 3 anaplastic astrocytoma, and 3 had grade 4 glioblastomas (GBM). All patients received surgery, and one patient received radiation therapy without concurrent chemotherapy during her pregnancy. All delivered healthy babies. Three of the 5 patients remain alive, and 2 of the 5 were progressionfree at the last follow-up. Conclusion: Treatment plans must be specifically tailored to the individual patient based on the glioma grade, the mother's desire to continue the pregnancy, and the risks of delaying treatment until after pregnancy. Additional studies need to be performed to definitively establish uniform guidelines for the treatment of pregnant patients with glioma.

Original languageEnglish (US)
Pages (from-to)3453-3457
Number of pages5
JournalAnticancer Research
Volume40
Issue number6
DOIs
StatePublished - Jun 2020

Keywords

  • Glioma
  • IDH mutated
  • Pregnancy
  • Radiation

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Fingerprint Dive into the research topics of 'Occurrence of glioma in pregnant patients: An institutional case series and review of the literature'. Together they form a unique fingerprint.

  • Cite this