Oceanalin A, a hybrid α,ω-bifunctionalized sphingoid tetrahydroisoquinoline β-glycoside from the marine sponge Oceanapia sp.

Tatyana N. Makarieva, Vladimir A. Denisenko, Pavel S. Dmitrenok, Alla G. Guzii, Elena A. Santalova, Valentin A. Stonik, John B. MacMillan, Tadeusz F. Molinski

Research output: Contribution to journalArticle

25 Scopus citations

Abstract

(Chemical Equation Presented) The novel antifungal compound oceanalin A, an unprecedented "hybrid sphingolipid", was isolated from the marine sponge Oceanapia sp. The structure was elucidated using NMR and MS spectral analysis and chemical degradation. Oceanalin A exhibits in vitro antifungal activity against Candida glabrata with an MIC of 30 μg/mL.

Original languageEnglish (US)
Pages (from-to)2897-2900
Number of pages4
JournalOrganic Letters
Volume7
Issue number14
DOIs
StatePublished - Jul 7 2005

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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    Makarieva, T. N., Denisenko, V. A., Dmitrenok, P. S., Guzii, A. G., Santalova, E. A., Stonik, V. A., MacMillan, J. B., & Molinski, T. F. (2005). Oceanalin A, a hybrid α,ω-bifunctionalized sphingoid tetrahydroisoquinoline β-glycoside from the marine sponge Oceanapia sp. Organic Letters, 7(14), 2897-2900. https://doi.org/10.1021/ol050796c