Oceanalin A, a hybrid α,ω-bifunctionalized sphingoid tetrahydroisoquinoline β-glycoside from the marine sponge Oceanapia sp.

Tatyana N. Makarieva, Vladimir A. Denisenko, Pavel S. Dmitrenok, Alla G. Guzii, Elena A. Santalova, Valentin A. Stonik, John B. MacMillan, Tadeusz F. Molinski

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Abstract

(Chemical Equation Presented) The novel antifungal compound oceanalin A, an unprecedented "hybrid sphingolipid", was isolated from the marine sponge Oceanapia sp. The structure was elucidated using NMR and MS spectral analysis and chemical degradation. Oceanalin A exhibits in vitro antifungal activity against Candida glabrata with an MIC of 30 μg/mL.

Original languageEnglish (US)
Pages (from-to)2897-2900
Number of pages4
JournalOrganic Letters
Volume7
Issue number14
DOIs
Publication statusPublished - Jul 7 2005

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ASJC Scopus subject areas

  • Molecular Medicine

Cite this

Makarieva, T. N., Denisenko, V. A., Dmitrenok, P. S., Guzii, A. G., Santalova, E. A., Stonik, V. A., ... Molinski, T. F. (2005). Oceanalin A, a hybrid α,ω-bifunctionalized sphingoid tetrahydroisoquinoline β-glycoside from the marine sponge Oceanapia sp. Organic Letters, 7(14), 2897-2900. https://doi.org/10.1021/ol050796c