TY - JOUR
T1 - Ocular manifestations and clinical characteristics of 535 cases of COVID-19 in Wuhan, China
T2 - a cross-sectional study
AU - Chen, Liwen
AU - Deng, Chaohua
AU - Chen, Xuhui
AU - Zhang, Xian
AU - Chen, Bo
AU - Yu, Huimin
AU - Qin, Yuanjun
AU - Xiao, Ke
AU - Zhang, Hong
AU - Sun, Xufang
N1 - Funding Information:
We are grateful to the medical staffs at Mobile Cabin Hospital of Optical Valley and Tongji Hospital for their assistance. This work was supported by the National Natural Science Foundation of China (81974136 and 81900859) and Huazhong University of Science and Technology (2020kfyXGYJ068). Hong Zhang and Xufang Sun designed and co‐ordinated the study. Liwen Chen, Chaohua Deng, Xuhui Chen, Huimin Yu, Yuanjun Qin and Ke Xiao collected the data. Liwen Chen performed and analysed the data. Liwen Chen, Bo Chen and Xian Zhang prepared the figures and tables. Liwen Chen, Chaohua Deng and Xuhui Chen wrote the manuscript. All authors reviewed the results, revised the manuscript and approved it for submission. The authors declare that they have no conflicts of interest with the contents of this article.
Publisher Copyright:
© 2020 Acta Ophthalmologica Scandinavica Foundation. Published by John Wiley & Sons Ltd
PY - 2020/12
Y1 - 2020/12
N2 - Purpose: To investigate the ocular manifestations and clinical characteristics of COVID-19 patients caused by SARS-CoV-2 in Wuhan, China. Methods: A total of 535 COVID-19 patients were recruited at Mobile Cabin Hospital and Tongji Hospital. Information on demographic characteristics, exposure history, ocular symptoms, eye drop medication, eye protections, chronic eye diseases, systemic concomitant symptoms, radiologic findings and SARS-CoV-2 detection in nasopharyngeal swabs by real-time PCR was collected from questionnaires and electronic medical records. Results: Of 535 patients, 27 patients (5.0%) presented with conjunctival congestion and 4 patients had conjunctival congestion as the initial symptom. The average duration of conjunctival congestion was 5.9 ± 4.5 days (mean [SD]). The other ocular symptoms, including increased conjunctival secretion, ocular pain, photophobia, dry eye and tearing, were also found in patients with conjunctival congestion. Notably, hand–eye contact was independently correlated with conjunctival congestion in COVID-19 patients. We also found that some COVID-19 patients had chronic eye diseases, including conjunctivitis (33, 6.2%), xerophthalmia (24, 4.5%) and keratitis (14, 2.6%). Similar to the published studies, the most common clinical symptoms were fever, cough and fatigue. A total of 343 patients (64.1%) had positive SARS-CoV-2 detection in nasopharyngeal swabs. Conclusions: Conjunctival congestion is one of the COVID-19-related ocular symptoms, which could occur as the initial symptoms. Frequent hand–eye contact may be the risk factor for conjunctival congestion in COVID-19 patients. Screening of patients with conjunctival congestion by ophthalmologists is advocated during the outbreak of COVID-19. It is essential to provide eye-care equipment and strengthen education on eye protection.
AB - Purpose: To investigate the ocular manifestations and clinical characteristics of COVID-19 patients caused by SARS-CoV-2 in Wuhan, China. Methods: A total of 535 COVID-19 patients were recruited at Mobile Cabin Hospital and Tongji Hospital. Information on demographic characteristics, exposure history, ocular symptoms, eye drop medication, eye protections, chronic eye diseases, systemic concomitant symptoms, radiologic findings and SARS-CoV-2 detection in nasopharyngeal swabs by real-time PCR was collected from questionnaires and electronic medical records. Results: Of 535 patients, 27 patients (5.0%) presented with conjunctival congestion and 4 patients had conjunctival congestion as the initial symptom. The average duration of conjunctival congestion was 5.9 ± 4.5 days (mean [SD]). The other ocular symptoms, including increased conjunctival secretion, ocular pain, photophobia, dry eye and tearing, were also found in patients with conjunctival congestion. Notably, hand–eye contact was independently correlated with conjunctival congestion in COVID-19 patients. We also found that some COVID-19 patients had chronic eye diseases, including conjunctivitis (33, 6.2%), xerophthalmia (24, 4.5%) and keratitis (14, 2.6%). Similar to the published studies, the most common clinical symptoms were fever, cough and fatigue. A total of 343 patients (64.1%) had positive SARS-CoV-2 detection in nasopharyngeal swabs. Conclusions: Conjunctival congestion is one of the COVID-19-related ocular symptoms, which could occur as the initial symptoms. Frequent hand–eye contact may be the risk factor for conjunctival congestion in COVID-19 patients. Screening of patients with conjunctival congestion by ophthalmologists is advocated during the outbreak of COVID-19. It is essential to provide eye-care equipment and strengthen education on eye protection.
KW - COVID-19
KW - SARS-CoV-2
KW - conjunctival congestion
KW - hand-eye contact
KW - ocular manifestations
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U2 - 10.1111/aos.14472
DO - 10.1111/aos.14472
M3 - Article
C2 - 32421258
AN - SCOPUS:85084820979
SN - 1755-375X
VL - 98
SP - e951-e959
JO - Acta Ophthalmologica
JF - Acta Ophthalmologica
IS - 8
ER -