Olfactory identification in young relatives at risk for schizophrenia

Matcheri S. Keshavan, Anvi Vora, Debra Montrose, Vaibhav A. Diwadkar, John Sweeney

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

Objective: Olfactory identification deficits (OIDs) are seen in schizophrenia, but it is unclear whether they are state- or trait-related. Methods: We examined the prevalence of OIDs, as assessed by the University of Pennsylvania Smell Identification Test (UPSIT), and their correlations with prodromal symptoms in young relatives at risk for schizophrenia or schizoaffective disorder (HR-S). Results: UPSIT scores were lower in HR- S than in healthy controls, but were non-significant after covarying the effects of age, gender and IQ. OID deficits in HR-S were correlated, after covarying out the effects of age and IQ, with prodromal disorganisation. Conclusion: The potential value of OID deficits as markers of psychopathological vulnerability in young relatives at risk for schizophrenia deserves further investigation.

Original languageEnglish (US)
Pages (from-to)121-124
Number of pages4
JournalActa Neuropsychiatrica
Volume21
Issue number3
DOIs
StatePublished - Jun 2009

Keywords

  • Cognition
  • Olfactory identification
  • Prodrome
  • Schizophrenia

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry

Fingerprint Dive into the research topics of 'Olfactory identification in young relatives at risk for schizophrenia'. Together they form a unique fingerprint.

Cite this