Oligodendrocyte lineage genes (OLIG) as molecular markers for human glial brain tumors

Q. Richard Lu, John K. Park, Elizabeth Noll, Jennifer A. Chan, John Alberta, Dongin Yuk, M. Garcia Alzamora, David N. Louis, Charles D. Stiles, David H. Rowitch, Peter M. Black

Research output: Contribution to journalArticle

141 Citations (Scopus)

Abstract

The most common primary tumors of the human brain are thought to be of glial cell origin. However, glial cell neoplasms cannot be fully classified by cellular morphology or with conventional markers for astrocytes, oligodendrocytes, or their progenitors. Recent insights into central nervous system tumorigenesis suggest that novel molecular markers might be found among factors that have roles in glial development. Oligodendrocyte lineage genes (Olig 1/2) encode basic helix-loop-helix transcription factors. In the rodent central nervous system, they are expressed exclusively in oligodendrocytes and oligodendrocyte progenitors, and Olig 1 can promote formation of an chondroitin sulfate proteoglycon-positive glial progenitor. Here we show that human OLIG genes are expressed strongly in oligodendroglioma, contrasting absent or low expression in astrocytoma. Our data provide evidence that neoplastic cells of oligodendroglioma resemble oligodendrocytes or their progenitor cells and may derive from cells of this lineage. They further suggest the diagnostic potential of OLIG markers to augment identification of oligodendroglial tumors.

Original languageEnglish (US)
Pages (from-to)10851-10856
Number of pages6
JournalProceedings of the National Academy of Sciences of the United States of America
Volume98
Issue number19
DOIs
StatePublished - Sep 11 2001

Fingerprint

Oligodendroglia
Brain Neoplasms
Neuroglia
Genes
Oligodendroglioma
Central Nervous System
Basic Helix-Loop-Helix Transcription Factors
Chondroitin Sulfates
Astrocytoma
Cell Lineage
Astrocytes
Rodentia
Neoplasms
Carcinogenesis
Stem Cells

ASJC Scopus subject areas

  • Genetics
  • General

Cite this

Oligodendrocyte lineage genes (OLIG) as molecular markers for human glial brain tumors. / Lu, Q. Richard; Park, John K.; Noll, Elizabeth; Chan, Jennifer A.; Alberta, John; Yuk, Dongin; Garcia Alzamora, M.; Louis, David N.; Stiles, Charles D.; Rowitch, David H.; Black, Peter M.

In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 98, No. 19, 11.09.2001, p. 10851-10856.

Research output: Contribution to journalArticle

Lu, QR, Park, JK, Noll, E, Chan, JA, Alberta, J, Yuk, D, Garcia Alzamora, M, Louis, DN, Stiles, CD, Rowitch, DH & Black, PM 2001, 'Oligodendrocyte lineage genes (OLIG) as molecular markers for human glial brain tumors', Proceedings of the National Academy of Sciences of the United States of America, vol. 98, no. 19, pp. 10851-10856. https://doi.org/10.1073/pnas.181340798
Lu, Q. Richard ; Park, John K. ; Noll, Elizabeth ; Chan, Jennifer A. ; Alberta, John ; Yuk, Dongin ; Garcia Alzamora, M. ; Louis, David N. ; Stiles, Charles D. ; Rowitch, David H. ; Black, Peter M. / Oligodendrocyte lineage genes (OLIG) as molecular markers for human glial brain tumors. In: Proceedings of the National Academy of Sciences of the United States of America. 2001 ; Vol. 98, No. 19. pp. 10851-10856.
@article{e16de68f891e4ba2aa14cde58a2d969a,
title = "Oligodendrocyte lineage genes (OLIG) as molecular markers for human glial brain tumors",
abstract = "The most common primary tumors of the human brain are thought to be of glial cell origin. However, glial cell neoplasms cannot be fully classified by cellular morphology or with conventional markers for astrocytes, oligodendrocytes, or their progenitors. Recent insights into central nervous system tumorigenesis suggest that novel molecular markers might be found among factors that have roles in glial development. Oligodendrocyte lineage genes (Olig 1/2) encode basic helix-loop-helix transcription factors. In the rodent central nervous system, they are expressed exclusively in oligodendrocytes and oligodendrocyte progenitors, and Olig 1 can promote formation of an chondroitin sulfate proteoglycon-positive glial progenitor. Here we show that human OLIG genes are expressed strongly in oligodendroglioma, contrasting absent or low expression in astrocytoma. Our data provide evidence that neoplastic cells of oligodendroglioma resemble oligodendrocytes or their progenitor cells and may derive from cells of this lineage. They further suggest the diagnostic potential of OLIG markers to augment identification of oligodendroglial tumors.",
author = "Lu, {Q. Richard} and Park, {John K.} and Elizabeth Noll and Chan, {Jennifer A.} and John Alberta and Dongin Yuk and {Garcia Alzamora}, M. and Louis, {David N.} and Stiles, {Charles D.} and Rowitch, {David H.} and Black, {Peter M.}",
year = "2001",
month = "9",
day = "11",
doi = "10.1073/pnas.181340798",
language = "English (US)",
volume = "98",
pages = "10851--10856",
journal = "Proceedings of the National Academy of Sciences of the United States of America",
issn = "0027-8424",
number = "19",

}

TY - JOUR

T1 - Oligodendrocyte lineage genes (OLIG) as molecular markers for human glial brain tumors

AU - Lu, Q. Richard

AU - Park, John K.

AU - Noll, Elizabeth

AU - Chan, Jennifer A.

AU - Alberta, John

AU - Yuk, Dongin

AU - Garcia Alzamora, M.

AU - Louis, David N.

AU - Stiles, Charles D.

AU - Rowitch, David H.

AU - Black, Peter M.

PY - 2001/9/11

Y1 - 2001/9/11

N2 - The most common primary tumors of the human brain are thought to be of glial cell origin. However, glial cell neoplasms cannot be fully classified by cellular morphology or with conventional markers for astrocytes, oligodendrocytes, or their progenitors. Recent insights into central nervous system tumorigenesis suggest that novel molecular markers might be found among factors that have roles in glial development. Oligodendrocyte lineage genes (Olig 1/2) encode basic helix-loop-helix transcription factors. In the rodent central nervous system, they are expressed exclusively in oligodendrocytes and oligodendrocyte progenitors, and Olig 1 can promote formation of an chondroitin sulfate proteoglycon-positive glial progenitor. Here we show that human OLIG genes are expressed strongly in oligodendroglioma, contrasting absent or low expression in astrocytoma. Our data provide evidence that neoplastic cells of oligodendroglioma resemble oligodendrocytes or their progenitor cells and may derive from cells of this lineage. They further suggest the diagnostic potential of OLIG markers to augment identification of oligodendroglial tumors.

AB - The most common primary tumors of the human brain are thought to be of glial cell origin. However, glial cell neoplasms cannot be fully classified by cellular morphology or with conventional markers for astrocytes, oligodendrocytes, or their progenitors. Recent insights into central nervous system tumorigenesis suggest that novel molecular markers might be found among factors that have roles in glial development. Oligodendrocyte lineage genes (Olig 1/2) encode basic helix-loop-helix transcription factors. In the rodent central nervous system, they are expressed exclusively in oligodendrocytes and oligodendrocyte progenitors, and Olig 1 can promote formation of an chondroitin sulfate proteoglycon-positive glial progenitor. Here we show that human OLIG genes are expressed strongly in oligodendroglioma, contrasting absent or low expression in astrocytoma. Our data provide evidence that neoplastic cells of oligodendroglioma resemble oligodendrocytes or their progenitor cells and may derive from cells of this lineage. They further suggest the diagnostic potential of OLIG markers to augment identification of oligodendroglial tumors.

UR - http://www.scopus.com/inward/record.url?scp=0035845569&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0035845569&partnerID=8YFLogxK

U2 - 10.1073/pnas.181340798

DO - 10.1073/pnas.181340798

M3 - Article

VL - 98

SP - 10851

EP - 10856

JO - Proceedings of the National Academy of Sciences of the United States of America

JF - Proceedings of the National Academy of Sciences of the United States of America

SN - 0027-8424

IS - 19

ER -