Oligodendrocytes and ischemic brain injury

Deborah Dewar, Suzanne M. Underhill, Mark P. Goldberg

Research output: Contribution to journalReview article

226 Scopus citations

Abstract

Oligodendrocytes, myelin-forming glial cells of the central nervous system, are vulnerable to damage in a variety of neurologic diseases. Much is known of primary myelin injury, which occurs in settings of genetic dysmyelination or demyelinating disease. There is growing awareness that oligodendrocytes are also targets of injury in acute ischemia. Recognition of oligodendrocyte damage in animal models of ischemia requires attention to their distinct histologic features or use of specific immunocytochemical markers. Like neurons, oligodendrocytes are highly sensitive to injury by oxidative stress, excitatory amino acids, trophic factor deprivation, and activation of apoptotic pathways. Understanding mechanisms of oligodendrocyte death may suggest new therapeutic strategies to preserve or restore white matter function and structure after ischemic insults.

Original languageEnglish (US)
Pages (from-to)263-274
Number of pages12
JournalJournal of Cerebral Blood Flow and Metabolism
Volume23
Issue number3
DOIs
StatePublished - Mar 1 2003

Keywords

  • Excitotoxicity
  • Glia
  • Ischemia
  • Oligodendrocyte
  • Oxidative stress
  • Protection
  • Stroke
  • White matter

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology
  • Cardiology and Cardiovascular Medicine

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