Omega-3 fatty acids and FFAR4

Dayoung Oh, Evelyn Walenta

Research output: Contribution to journalShort survey

12 Citations (Scopus)

Abstract

The beneficial roles of omega-3 fatty acids (ω3-FAs) on obesity, type 2 diabetes, and other metabolic diseases are well known. Most of these effects can be explained by their anti-inflammatory effects triggered through their receptor, free fatty acid receptor 4 (FFAR4) activation. Although the whole mechanism of action is not fully described yet, it has been shown that stimulation of ω3-FA to FFAR4 is followed by receptor phosphorylation. This makes FFAR4 to be capable of interacting with β-arrestin-2, which in turn, results in association of β-arrestin-2 with TAB1. This stealing of an important partaker of the inflammatory cascade leads to interruption of the pathway, resulting in reduced inflammation. Besides this regulation of the anti-inflammatory response, FFAR4 signaling also has been shown to regulate glucose homeostasis, adiposity, gastrointestinal peptide secretion, and taste preference. In this review, we summarize the current knowledge about the interaction of ω3-FAs with FFAR4 and the consequent opportunities for the application of ω3-FAs and possible FFAR4 targets.

Original languageEnglish (US)
Article number115
JournalFrontiers in Endocrinology
Volume5
Issue numberJUL
DOIs
StatePublished - Jan 1 2014

Fingerprint

Omega-3 Fatty Acids
Nonesterified Fatty Acids
Fatty Acids
Anti-Inflammatory Agents
Theft
Metabolic Diseases
Adiposity
Type 2 Diabetes Mellitus
Homeostasis
Obesity
Phosphorylation
Inflammation
Glucose
Peptides

Keywords

  • Anti-inflammation
  • Ffar4
  • Insulin resistance
  • Obesity
  • Omega-3 fatty acids

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism

Cite this

Omega-3 fatty acids and FFAR4. / Oh, Dayoung; Walenta, Evelyn.

In: Frontiers in Endocrinology, Vol. 5, No. JUL, 115, 01.01.2014.

Research output: Contribution to journalShort survey

Oh, Dayoung ; Walenta, Evelyn. / Omega-3 fatty acids and FFAR4. In: Frontiers in Endocrinology. 2014 ; Vol. 5, No. JUL.
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