On acetyl-CoA as a gauge of cellular metabolic state

L. Cai, B. P. Tu

Research output: Contribution to journalArticle

53 Citations (Scopus)

Abstract

Many activities within a cell must be intimately coordinated with its metabolic state. Understanding these connections to metabolism is critical to deciphering the regulation of a variety of cellular processes. However, despite intensive research in these areas, the precise mechanisms by which a cell monitors its metabolic state remain controversial and poorly understood. Herein, we discuss the thesis that intracellular levels of the metabolite acetyl-CoA represent a critical gauge of cellular metabolic state, which is cleverly monitored by the cell through dynamic acetylation modifications to direct a variety of outputs connected to energy metabolism, cell growth, and survival.

Original languageEnglish (US)
Pages (from-to)195-202
Number of pages8
JournalCold Spring Harbor Symposia on Quantitative Biology
Volume76
DOIs
StatePublished - 2011

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Acetylation
Acetyl Coenzyme A
Cell growth
Metabolites
Metabolism
Gages
Energy Metabolism
Cell Survival
Growth
Research

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Biochemistry

Cite this

On acetyl-CoA as a gauge of cellular metabolic state. / Cai, L.; Tu, B. P.

In: Cold Spring Harbor Symposia on Quantitative Biology, Vol. 76, 2011, p. 195-202.

Research output: Contribution to journalArticle

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