On improving the speed and reliability of T 2-relaxation-under- spin-tagging (TRUST) MRI

Feng Xu, Jinsoo Uh, Peiying Liu, Hanzhang Lu

Research output: Contribution to journalArticle

39 Citations (Scopus)

Abstract

A T 2-relaxation-under-spin-tagging technique was recently developed to estimate cerebral blood oxygenation, providing potentials for noninvasive assessment of the brain's oxygen consumption. A limitation of the current sequence is the need for long repetition time, as shorter repetition time causes an over-estimation in blood R 2. This study proposes a post-saturation T 2-relaxation-under-spin-tagging by placing a non-selective 90° pulse after the signal acquisition to reset magnetization in the whole brain. This scheme was found to eliminate estimation bias at a slight cost of precision. To improve the precision, echo time of the sequence was optimized and it was found that a modest echo time shortening of 3.4 ms can reduce the estimation error by 49%. We recommend the use of postsaturation T 2-relaxation-under-spin-tagging sequence with a repetition time of 3000 ms and a echo time of 3.6 ms, which allows the determination of global venous oxygenation with scan duration of 1 min 12 s and an estimation precision of ±1% (in units of oxygen saturation percentage).

Original languageEnglish (US)
Pages (from-to)198-204
Number of pages7
JournalMagnetic Resonance in Medicine
Volume68
Issue number1
DOIs
StatePublished - Jul 2012

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Brain
Oxygen Consumption
Oxygen
Costs and Cost Analysis

Keywords

  • Arterial spin labeling
  • Brain
  • Magnetization saturation
  • Noninvasive measurement
  • Oxygen saturation
  • Oxygenation

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

On improving the speed and reliability of T 2-relaxation-under- spin-tagging (TRUST) MRI. / Xu, Feng; Uh, Jinsoo; Liu, Peiying; Lu, Hanzhang.

In: Magnetic Resonance in Medicine, Vol. 68, No. 1, 07.2012, p. 198-204.

Research output: Contribution to journalArticle

Xu, Feng ; Uh, Jinsoo ; Liu, Peiying ; Lu, Hanzhang. / On improving the speed and reliability of T 2-relaxation-under- spin-tagging (TRUST) MRI. In: Magnetic Resonance in Medicine. 2012 ; Vol. 68, No. 1. pp. 198-204.
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