TY - JOUR
T1 - On naming H2 haplotypes
T2 - Functional significance of MHC class Ib alleles
AU - Lindahl, Kirsten Fischer
N1 - Funding Information:
Acknowledgments This work was supported in part by NIH grant AI37818. Qa1 and TL types are based on data gathered with the expert assistance of Ms. Barbara Hausmann while I was a member of the Basel Institute for Immunology, which was founded and is supported by F. Hoffman-La Roche, Inc., Basel, Switzerland. I thank my colleagues Claire Amadou, Elsy Jones, Attila Kumanovics, Doris Lam-bracht, and Masayasu Yoshino for discussions, and Evan Hermel for references about the Mhc of mice and humans.
PY - 1997
Y1 - 1997
N2 - George D. Snell began defining and naming the H2 haplotypes many years ago by histogenetic typing. Since then, a few haplotypes have been given an additional letter, such as be for strain 129, to show that they are minor variants from the prototype (b). But by and large, differences in nonclassical class I antigens have been known (only?) to those in the field without being acknowledged by a separate haplotype symbol. Thus, strains BALB/c and NZB/B1NJ are both considered H2(d) and strains C3H/HeJ and B1O.BR are both called H2(k), although each pair differs in the TL and Qa1 antigens. In parallel with the interest in nonclassical class I antigens, the need for an appropriate haplotype nomenclature is growing. The haplotypes that require splitting are b, d, k, q, and s; the symbol be should be retained and used, and, for the other haplotypes, the suffix 2 denotes a Qa1a haplotype with highly TL-positive thymocytes.
AB - George D. Snell began defining and naming the H2 haplotypes many years ago by histogenetic typing. Since then, a few haplotypes have been given an additional letter, such as be for strain 129, to show that they are minor variants from the prototype (b). But by and large, differences in nonclassical class I antigens have been known (only?) to those in the field without being acknowledged by a separate haplotype symbol. Thus, strains BALB/c and NZB/B1NJ are both considered H2(d) and strains C3H/HeJ and B1O.BR are both called H2(k), although each pair differs in the TL and Qa1 antigens. In parallel with the interest in nonclassical class I antigens, the need for an appropriate haplotype nomenclature is growing. The haplotypes that require splitting are b, d, k, q, and s; the symbol be should be retained and used, and, for the other haplotypes, the suffix 2 denotes a Qa1a haplotype with highly TL-positive thymocytes.
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U2 - 10.1007/s002510050242
DO - 10.1007/s002510050242
M3 - Article
C2 - 9148789
AN - SCOPUS:8244234464
SN - 0093-7711
VL - 46
SP - 53
EP - 62
JO - Immunogenetics
JF - Immunogenetics
IS - 1
ER -