TY - JOUR
T1 - On the memory of a chronic illness.
AU - Goldschmidt-Clermont, Pascal J.
AU - Peterson, Eric D.
PY - 2003/11/12
Y1 - 2003/11/12
N2 - The elderly are particularly susceptible to disease, yet the biological mechanisms that bring about this susceptibility remain unclear. Using atherosclerosis as a model chronic illness, we review how recent studies of bone marrow-derived vascular repair systems in mice and humans provide new insights into the causes and potential cures for age-related illness. Organisms are born with a finite capacity for stem cell-mediated repair after chronic exposure to tissue injury. Once that capacity is exhausted, a cycle of pathological inflammation ensues and leads to overt disease manifestations. Augmentation of stem cell-mediated repair systems may provide a novel means of treating or preventing many age-related illnesses.
AB - The elderly are particularly susceptible to disease, yet the biological mechanisms that bring about this susceptibility remain unclear. Using atherosclerosis as a model chronic illness, we review how recent studies of bone marrow-derived vascular repair systems in mice and humans provide new insights into the causes and potential cures for age-related illness. Organisms are born with a finite capacity for stem cell-mediated repair after chronic exposure to tissue injury. Once that capacity is exhausted, a cycle of pathological inflammation ensues and leads to overt disease manifestations. Augmentation of stem cell-mediated repair systems may provide a novel means of treating or preventing many age-related illnesses.
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U2 - 10.1126/sageke.2003.45.re8
DO - 10.1126/sageke.2003.45.re8
M3 - Review article
C2 - 14614128
AN - SCOPUS:1542438627
SN - 1539-6150
VL - 2003
SP - re8
JO - Science of aging knowledge environment : SAGE KE
JF - Science of aging knowledge environment : SAGE KE
IS - 45
ER -